A common limiter circuit for opioid choice and relapse identified in a rodent addiction model

Jasper A. Heinsbroek; Giuseppe Giannotti; Mitchel R. Mandel; Megan Josey; Gary Aston-Jones; Morgan H. James; Jamie Peters

doi:10.1038/s41467-021-25080-x

Nature Communications (Aug 2021)

A common limiter circuit for opioid choice and relapse identified in a rodent addiction model

Jasper A. Heinsbroek,
Giuseppe Giannotti,
Mitchel R. Mandel,
Megan Josey,
Gary Aston-Jones,
Morgan H. James,
Jamie Peters

Affiliations

Jasper A. Heinsbroek: Department of Anesthesiology, University of Colorado Anschutz Medical Campus
Giuseppe Giannotti: Department of Anesthesiology, University of Colorado Anschutz Medical Campus
Mitchel R. Mandel: Department of Anesthesiology, University of Colorado Anschutz Medical Campus
Megan Josey: Department of Anesthesiology, University of Colorado Anschutz Medical Campus
Gary Aston-Jones: Brain Health Institute, Rutgers University and Rutgers Biomedical and Health Sciences
Morgan H. James: Brain Health Institute, Rutgers University and Rutgers Biomedical and Health Sciences
Jamie Peters: Department of Anesthesiology, University of Colorado Anschutz Medical Campus

DOI: https://doi.org/10.1038/s41467-021-25080-x
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 10

Abstract

Read online

The neural circuits underlying rewarding effects of drugs of abuse and natural rewards are not fully understood. Here the authors investigate the role of the infralimbic cortex to nucleus accumbens shell pathway during heroin or food choice in rats.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal