Nature Communications (Jun 2020)
NOTCH1 activation compensates BRCA1 deficiency and promotes triple-negative breast cancer formation
- Kai Miao,
- Josh Haipeng Lei,
- Monica Vishnu Valecha,
- Aiping Zhang,
- Jun Xu,
- Lijian Wang,
- Xueying Lyu,
- Si Chen,
- Zhengqiang Miao,
- Xin Zhang,
- Sek Man Su,
- Fangyuan Shao,
- Barani Kumar Rajendran,
- Jiaolin Bao,
- Jianming Zeng,
- Heng Sun,
- Ping Chen,
- Kaeling Tan,
- Qiang Chen,
- Koon Ho Wong,
- Xiaoling Xu,
- Chu-Xia Deng
Affiliations
- Kai Miao
- Cancer Center, Faculty of Health Sciences, University of Macau
- Josh Haipeng Lei
- Cancer Center, Faculty of Health Sciences, University of Macau
- Monica Vishnu Valecha
- Cancer Center, Faculty of Health Sciences, University of Macau
- Aiping Zhang
- Cancer Center, Faculty of Health Sciences, University of Macau
- Jun Xu
- Cancer Center, Faculty of Health Sciences, University of Macau
- Lijian Wang
- Cancer Center, Faculty of Health Sciences, University of Macau
- Xueying Lyu
- Cancer Center, Faculty of Health Sciences, University of Macau
- Si Chen
- Cancer Center, Faculty of Health Sciences, University of Macau
- Zhengqiang Miao
- Cancer Center, Faculty of Health Sciences, University of Macau
- Xin Zhang
- Cancer Center, Faculty of Health Sciences, University of Macau
- Sek Man Su
- Cancer Center, Faculty of Health Sciences, University of Macau
- Fangyuan Shao
- Cancer Center, Faculty of Health Sciences, University of Macau
- Barani Kumar Rajendran
- Cancer Center, Faculty of Health Sciences, University of Macau
- Jiaolin Bao
- Cancer Center, Faculty of Health Sciences, University of Macau
- Jianming Zeng
- Cancer Center, Faculty of Health Sciences, University of Macau
- Heng Sun
- Cancer Center, Faculty of Health Sciences, University of Macau
- Ping Chen
- Cancer Center, Faculty of Health Sciences, University of Macau
- Kaeling Tan
- Cancer Center, Faculty of Health Sciences, University of Macau
- Qiang Chen
- Cancer Center, Faculty of Health Sciences, University of Macau
- Koon Ho Wong
- Cancer Center, Faculty of Health Sciences, University of Macau
- Xiaoling Xu
- Cancer Center, Faculty of Health Sciences, University of Macau
- Chu-Xia Deng
- Cancer Center, Faculty of Health Sciences, University of Macau
- DOI
- https://doi.org/10.1038/s41467-020-16936-9
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 15
Abstract
BRCA1 mutation carriers have higher chances of developing triple-negative breast cancer (TNBC). Here, the authors use the Sleeping Beauty mutagenesis system in Brca1 deficient mice and identify 169 putative driver genes, of which NOTCH1 accelerates TNBC formation through promoting epithelial-mesenchymal transition and cell cycle progression.
