Deep terminal negativity of the P‐wave in V1 and stroke risk: The National Health and Nutrition Examination survey III

Abstract

Abstract Background Deep terminal negativity of the P‐wave in V1 (DTNPV1) was considered if the absolute value of the depth of the negative phase was >100 μV in the presence of a biphasic P‐wave in V1. In this study, we aimed to determine the association between DTNPV1, a simpler P‐wave index, and the risk of stroke. Methods We compared P‐wave indices between participants with and without a self‐reported history of stroke in the United States Third National Health and Nutrition Examination Survey (NHANES III). The association between DTNPV1 and stroke was quantified with logistic regression models. Results In total, 7732 participants were included (307 with a history of stroke). Patients with stroke had deeper terminal negativity of the P‐wave in V1 (52.3 ± 33.9 μV vs. 41.4 ± 27.0 μV, p 0 μV but ≤100 μV and > 100 μV) in V1 (2.8%, 3.3%, and 10.3%, respectively, p = .005). Conclusion In NHANES III, DTNPV1 was associated with a higher prevalence of stroke, suggesting that DTNPV1 might be a convenient marker to distinguish the risk of stroke.

Keywords

• electrocardiogram
• P‐wave indices
• risk of stroke