Safety and biocompatibility of a bionic eye: Imaging, intraocular pressure, and histology data
Samuel C. Eggenberger,
Natalie L. James,
Cherry Ho,
Steven S. Eamegdool,
Veronika Tatarinoff,
Naomi A. Craig,
Barry S. Gow,
Susan Wan,
Christopher W.D. Dodds,
Donna La Hood,
Aaron Gilmour,
Shannon L. Donahoe,
Mark Krockenberger,
Krishna Tumuluri,
Melville J. da Cruz,
John R. Grigg,
Peter McCluskey,
Nigel H. Lovell,
Michele C. Madigan,
Adrian T. Fung,
Gregg J. Suaning
Affiliations
Samuel C. Eggenberger
School of Biomedical Engineering, Faculty of Engineering, University of Sydney, Sydney, Australia; Corresponding authors.
Natalie L. James
Graduate School of Biomedical Engineering, University of New South Wales (UNSW), Sydney, Australia
Cherry Ho
Graduate School of Biomedical Engineering, University of New South Wales (UNSW), Sydney, Australia
Steven S. Eamegdool
Save Sight Institute, The University of Sydney, Specialty of Clinical Ophthalmology and Eye Health, Faculty of Medicine and Health
Veronika Tatarinoff
Graduate School of Biomedical Engineering, University of New South Wales (UNSW), Sydney, Australia
Naomi A. Craig
Graduate School of Biomedical Engineering, University of New South Wales (UNSW), Sydney, Australia
Barry S. Gow
Graduate School of Biomedical Engineering, University of New South Wales (UNSW), Sydney, Australia
Susan Wan
The Westmead Institute for medical research, Westmead, Australia
Christopher W.D. Dodds
Graduate School of Biomedical Engineering, University of New South Wales (UNSW), Sydney, Australia
Donna La Hood
Brien Holden Vision Institute, Sydney, Australia; School of Optometry and Vision Science, University of New South Wales (UNSW), Sydney, Australia
Aaron Gilmour
School of Biomedical Engineering, Faculty of Engineering, University of Sydney, Sydney, Australia; Graduate School of Biomedical Engineering, University of New South Wales (UNSW), Sydney, Australia
Shannon L. Donahoe
Veterinary Pathology Diagnostic Services, Sydney School of Veterinary Science, University of Sydney, Sydney, Australia
Mark Krockenberger
Veterinary Pathology Diagnostic Services, Sydney School of Veterinary Science, University of Sydney, Sydney, Australia
Krishna Tumuluri
Save Sight Institute, The University of Sydney, Specialty of Clinical Ophthalmology and Eye Health, Faculty of Medicine and Health; Westmead Clinical School, Specialty of Clinical Ophthalmology and Eye Health, Faculty of Medicine and Health, University of Sydney, Sydney, Australia; Department of Ophthalmology, Faculty of Medicine and Health Sciences, Macquarie University, Sydney, Australia
Melville J. da Cruz
Department of Otolaryngology, Westmead Hospital, University of Sydney, Sydney, Australia; Faculty of Medicine and Health, University of Sydney, Sydney, Australia
John R. Grigg
Save Sight Institute, The University of Sydney, Specialty of Clinical Ophthalmology and Eye Health, Faculty of Medicine and Health; Faculty of Medicine and Health, University of Sydney, Sydney, Australia
Peter McCluskey
Save Sight Institute, The University of Sydney, Specialty of Clinical Ophthalmology and Eye Health, Faculty of Medicine and Health; Faculty of Medicine and Health, University of Sydney, Sydney, Australia
Nigel H. Lovell
Graduate School of Biomedical Engineering, University of New South Wales (UNSW), Sydney, Australia
Michele C. Madigan
Save Sight Institute, The University of Sydney, Specialty of Clinical Ophthalmology and Eye Health, Faculty of Medicine and Health; School of Optometry and Vision Science, University of New South Wales (UNSW), Sydney, Australia
Adrian T. Fung
Save Sight Institute, The University of Sydney, Specialty of Clinical Ophthalmology and Eye Health, Faculty of Medicine and Health; Westmead Clinical School, Specialty of Clinical Ophthalmology and Eye Health, Faculty of Medicine and Health, University of Sydney, Sydney, Australia; Department of Ophthalmology, Faculty of Medicine and Health Sciences, Macquarie University, Sydney, Australia
Gregg J. Suaning
School of Biomedical Engineering, Faculty of Engineering, University of Sydney, Sydney, Australia; Graduate School of Biomedical Engineering, University of New South Wales (UNSW), Sydney, Australia; Corresponding authors.
The data presented here are related and supplementary data to the research article “Implantation and long-term assessment of the stability and biocompatibility of a novel 98 channel suprachoroidal visual prosthesis in sheep” [1]. In Eggenberger et al., nine sheep of the Suffolk (N=2) and Dorper (N=7) breeds were implanted in the left eye with an electrically inactive, suprachoroidal retinal stimulator (Bionic Eye) for durations of up to 100 days. The surgical safety, implant stability and device biocompatibility were assessed. Intraocular pressure measurements, indirect and infrared ophthalmoscopy and optical coherence tomography were performed at fixed time points to evaluate the clinical effects of the surgery and device implantation. Post-mortem eye tissue collection and histology was performed to measure the effects of the intervention at the cellular level. The data, including a comprehensive collection of fundus, infrared, optical coherence tomography and histology images can be used as a reference for comparison with other research, for example, active retinal stimulators. Furthermore, these data can be used to evaluate the suitability of the sheep model, in particular Dorper sheep, for future research.
