PLoS ONE (Jan 2012)

Plasma proteomic profiling in HIV-1 infected methamphetamine abusers.

  • Gwenael Pottiez,
  • Teena Jagadish,
  • Fang Yu,
  • Scott Letendre,
  • Ronald Ellis,
  • Nichole A Duarte,
  • Igor Grant,
  • Howard E Gendelman,
  • Howard S Fox,
  • Pawel Ciborowski

DOI
https://doi.org/10.1371/journal.pone.0031031
Journal volume & issue
Vol. 7, no. 2
p. e31031

Abstract

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We wanted to determine whether methamphetamine use affects a subset of plasma proteins in HIV-infected persons. Plasma samples from two visits were identified for subjects from four groups: HIV+, ongoing, persistent METH use; HIV+, short-term METH abstinent; HIV+, long term METH abstinence; HIV negative, no history of METH use. Among 390 proteins identified, 28 showed significant changes in expression in the HIV+/persistent METH+ group over the two visits, which were not attributable to HIV itself. These proteins were involved in complement, coagulation pathways and oxidative stress. Continuous METH use is an unstable condition, altering levels of a number of plasma proteins.