Increased mitochondrial calcium levels associated with neuronal death in a mouse model of Alzheimer’s disease

Maria Calvo-Rodriguez; Steven S. Hou; Austin C. Snyder; Elizabeth K. Kharitonova; Alyssa N. Russ; Sudeshna Das; Zhanyun Fan; Alona Muzikansky; Monica Garcia-Alloza; Alberto Serrano-Pozo; Eloise Hudry; Brian J. Bacskai

doi:10.1038/s41467-020-16074-2

Nature Communications (May 2020)

Increased mitochondrial calcium levels associated with neuronal death in a mouse model of Alzheimer’s disease

Maria Calvo-Rodriguez,
Steven S. Hou,
Austin C. Snyder,
Elizabeth K. Kharitonova,
Alyssa N. Russ,
Sudeshna Das,
Zhanyun Fan,
Alona Muzikansky,
Monica Garcia-Alloza,
Alberto Serrano-Pozo,
Eloise Hudry,
Brian J. Bacskai

Affiliations

Maria Calvo-Rodriguez: Department of Neurology, Massachusetts General Hospital and Harvard Medical School
Steven S. Hou: Department of Neurology, Massachusetts General Hospital and Harvard Medical School
Austin C. Snyder: Department of Neurology, Massachusetts General Hospital and Harvard Medical School
Elizabeth K. Kharitonova: Department of Neurology, Massachusetts General Hospital and Harvard Medical School
Alyssa N. Russ: Department of Neurology, Massachusetts General Hospital and Harvard Medical School
Sudeshna Das: Department of Neurology, Massachusetts General Hospital and Harvard Medical School
Zhanyun Fan: Department of Neurology, Massachusetts General Hospital and Harvard Medical School
Alona Muzikansky: Department of Biostatistics, Harvard School of Public Health
Monica Garcia-Alloza: Division of Physiology, School of Medicine, Instituto de Investigacion Biomedica de Cadiz (INIBICA), Universidad de Cadiz
Alberto Serrano-Pozo: Department of Neurology, Massachusetts General Hospital and Harvard Medical School
Eloise Hudry: Department of Neurology, Massachusetts General Hospital and Harvard Medical School
Brian J. Bacskai: Department of Neurology, Massachusetts General Hospital and Harvard Medical School

DOI: https://doi.org/10.1038/s41467-020-16074-2
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 17

Abstract

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Calvo-Rodriguez et al. show elevated calcium levels in neuronal mitochondria in a mouse model of cerebral β-amyloidosis after plaque deposition, which precede rare neuron death events in this model. The mechanism involves toxic extracellular Aβ oligomers and the mitochondrial calcium uniporter.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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