Recent Advances in the Clinical Translation of Silicon Fluoride Acceptor (SiFA) <sup>18</sup>F-Radiopharmaceuticals

Lexi Gower-Fry; Travis Kronemann; Andreas Dorian; Yinglan Pu; Carolin Jaworski; Carmen Wängler; Peter Bartenstein; Leonie Beyer; Simon Lindner; Klaus Jurkschat; Björn Wängler; Justin J. Bailey; Ralf Schirrmacher

doi:10.3390/ph14070701

Pharmaceuticals (Jul 2021)

Recent Advances in the Clinical Translation of Silicon Fluoride Acceptor (SiFA) <sup>18</sup>F-Radiopharmaceuticals

Lexi Gower-Fry,
Travis Kronemann,
Andreas Dorian,
Yinglan Pu,
Carolin Jaworski,
Carmen Wängler,
Peter Bartenstein,
Leonie Beyer,
Simon Lindner,
Klaus Jurkschat,
Björn Wängler,
Justin J. Bailey,
Ralf Schirrmacher

Affiliations

Lexi Gower-Fry: Department of Oncology, Division of Oncological Imaging, University of Alberta, Edmonton, AB T6G 1Z2, Canada
Travis Kronemann: Department of Oncology, Division of Oncological Imaging, University of Alberta, Edmonton, AB T6G 1Z2, Canada
Andreas Dorian: Department of Oncology, Division of Oncological Imaging, University of Alberta, Edmonton, AB T6G 1Z2, Canada
Yinglan Pu: Department of Oncology, Division of Oncological Imaging, University of Alberta, Edmonton, AB T6G 1Z2, Canada
Carolin Jaworski: Department of Oncology, Division of Oncological Imaging, University of Alberta, Edmonton, AB T6G 1Z2, Canada
Carmen Wängler: Biomedical Chemistry, Department of Clinical Radiology and Nuclear Medicine, Medical Faculty Mannheim of Heidelberg University, Theodor-Kutzer-Ufer 1-3, 68167 Mannheim, Germany
Peter Bartenstein: Department of Nuclear Medicine, University Hospital, LMU Munich, Marchioninistraße 15, 81377 Munich, Germany
Leonie Beyer: Department of Nuclear Medicine, University Hospital, LMU Munich, Marchioninistraße 15, 81377 Munich, Germany
Simon Lindner: Department of Nuclear Medicine, University Hospital, LMU Munich, Marchioninistraße 15, 81377 Munich, Germany
Klaus Jurkschat: Fakultät für Chemie und Chemische Biologie, Technische Universität Dortmund, 44227 Dortmund, Germany
Björn Wängler: Molecular Imaging and Radiochemistry, Department of Clinical Radiology and Nuclear Medicine, Medical Faculty Mannheim of Heidelberg University, Theodor-Kutzer-Ufer 1-3, 68167 Mannheim, Germany
Justin J. Bailey: Department of Oncology, Division of Oncological Imaging, University of Alberta, Edmonton, AB T6G 1Z2, Canada
Ralf Schirrmacher: Department of Oncology, Division of Oncological Imaging, University of Alberta, Edmonton, AB T6G 1Z2, Canada

DOI: https://doi.org/10.3390/ph14070701
Journal volume & issue: Vol. 14, no. 7
p. 701

Abstract

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The incorporation of silicon fluoride acceptor (SiFA) moieties into a variety of molecules, such as peptides, proteins and biologically relevant small molecules, has improved the generation of 18F-radiopharmaceuticals for medical imaging. The efficient isotopic exchange radiofluorination process, in combination with the enhanced [18F]SiFA in vivo stability, make it a suitable strategy for fluorine-18 incorporation. This review will highlight the clinical applicability of [18F]SiFA-labeled compounds and discuss the significant radiotracers currently in clinical use.

Published in Pharmaceuticals

ISSN: 1424-8247 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Medicine: Pharmacy and materia medica
Website: http://www.mdpi.com/journal/pharmaceuticals/

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