Nature Communications (Feb 2021)
The genome-wide impact of trisomy 21 on DNA methylation and its implications for hematopoiesis
- Ivo S. Muskens,
- Shaobo Li,
- Thomas Jackson,
- Natalina Elliot,
- Helen M. Hansen,
- Swe Swe Myint,
- Priyatama Pandey,
- Jeremy M. Schraw,
- Ritu Roy,
- Joaquin Anguiano,
- Katerina Goudevenou,
- Kimberly D. Siegmund,
- Philip J. Lupo,
- Marella F. T. R. de Bruijn,
- Kyle M. Walsh,
- Paresh Vyas,
- Xiaomei Ma,
- Anindita Roy,
- Irene Roberts,
- Joseph L. Wiemels,
- Adam J. de Smith
Affiliations
- Ivo S. Muskens
- Center for Genetic Epidemiology, Department of Preventive Medicine, Keck School of Medicine of the University of Southern California
- Shaobo Li
- Center for Genetic Epidemiology, Department of Preventive Medicine, Keck School of Medicine of the University of Southern California
- Thomas Jackson
- Department of Paediatrics and MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, Oxford University and BRC Blood Theme, NIHR Oxford Biomedical Centre
- Natalina Elliot
- Department of Paediatrics and MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, Oxford University and BRC Blood Theme, NIHR Oxford Biomedical Centre
- Helen M. Hansen
- Department of Neurological Surgery, University of California San Francisco
- Swe Swe Myint
- Center for Genetic Epidemiology, Department of Preventive Medicine, Keck School of Medicine of the University of Southern California
- Priyatama Pandey
- Center for Genetic Epidemiology, Department of Preventive Medicine, Keck School of Medicine of the University of Southern California
- Jeremy M. Schraw
- Department of Pediatrics, Section of Hematology-Oncology, Baylor College of Medicine
- Ritu Roy
- Computational Biology and Informatics, University of California San Francisco
- Joaquin Anguiano
- Department of Neurological Surgery, University of California San Francisco
- Katerina Goudevenou
- Department of Paediatrics and MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, Oxford University and BRC Blood Theme, NIHR Oxford Biomedical Centre
- Kimberly D. Siegmund
- Department of Preventive Medicine, Keck School of Medicine of the University of Southern California
- Philip J. Lupo
- Department of Pediatrics, Section of Hematology-Oncology, Baylor College of Medicine
- Marella F. T. R. de Bruijn
- MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford
- Kyle M. Walsh
- Department of Neurosurgery, Duke University
- Paresh Vyas
- MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford
- Xiaomei Ma
- Department of Chronic Disease Epidemiology, Yale School of Public Health
- Anindita Roy
- Department of Paediatrics and MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, Oxford University and BRC Blood Theme, NIHR Oxford Biomedical Centre
- Irene Roberts
- Department of Paediatrics and MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, Oxford University and BRC Blood Theme, NIHR Oxford Biomedical Centre
- Joseph L. Wiemels
- Center for Genetic Epidemiology, Department of Preventive Medicine, Keck School of Medicine of the University of Southern California
- Adam J. de Smith
- Center for Genetic Epidemiology, Department of Preventive Medicine, Keck School of Medicine of the University of Southern California
- DOI
- https://doi.org/10.1038/s41467-021-21064-z
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 15
Abstract
Down syndrome has a high co-morbidity with immune and hematopoietic disorders. Here, the authors perform an epigenome-wide association study in newborns with and without Down syndrome to find differential methylation across the genome, including in hematopoietic regulators RUNX1 and FLI1.
