Menopause Review (Jun 2010)
Porównanie wpływu transdermalnej i doustnej hormonalnej terapii zastępczej na samopoczucie kobiet po operacji usunięcia macicy wraz z przydatkami
Abstract
Introduction: Patients who have undergone hysterectomy with adnexectomy have the same symptoms aswomen during the perimenopausal period. In order to alleviate these symptoms and prevent distant effects ofoestrogen deficiency, the use of continuous oestrogen therapy is recommended. Aim of the study: The aim of this work was to compare the effects of oral and transdermal hormonal replacementtherapy in patients after hystero-adnexectomy. Material and methods: The study covered a group of 80 patients, who were divided into two subgroups. Thefirst subgroup was administered a transdermal preparation with estradiol and the second one – an oral preparation. The control group consisted of 60 patients, who did not consent to the hormonal therapy (HT). Thedegree of intensity of climacteric symptoms was evaluated in each group at the time of the operation, 3 monthsand 6 months after the operation. Severity of symptoms was rated using Kuppermann scale. Results: There were no differences in the incidence of climacteric symptoms in particular degrees betweenthe two groups before the surgery. After 3 months, a decrease in the incidence of severe and moderate climacteric symptoms in patients receiving HT was observed. After 6 months, only 8% of patients with transdermal HTand 6% of patients with oral HT reported climacteric symptoms, in the control group patients reported a furtherincrease in complaints. Conclusions: Women applying oestrogen therapy after surgery are less vulnerable to incidence of menopausalsymptoms. The expected results are achieved earlier after oral HT, while the effects are far more satisfactorywhen applying transdermal HT.
