Diabetes, Metabolic Syndrome and Obesity (Aug 2022)
Correlation Between Blood Glucose Control and Levels of Carbohydrate Antigen 19-9 and Carcinoembryonic Antigen in Patients with Type-2 Diabetes Mellitus
Abstract
Dong Zhang Department of Internal Medicine, The Second Hospital of Beijing, Beijing, 100031, People’s Republic of ChinaCorrespondence: Dong Zhang, Department of Internal Medicine, The Second Hospital of Beijing, Beijing, 100031, People’s Republic of China, Tel +86 10 66061122, Email [email protected]: To investigate The relationship between glycemic control and serum levels of carbohydrate antigen 19– 9 (CA19-9) and carcinoembryonic antigen (CEA) in patients with type-2 diabetes mellitus (T2DM).Methods: A total of 211 patients with T2DM who were hospitalized were enrolled and divided into two groups according to the glycosylated hemoglobin AlC (HbAlC) levels: Group A (HbAlC ≥ 7.5%) and Group B (6.5% 0.05). A correlation analysis revealed that both CA19-9 and CEA were positively correlated with HbAlC (P < 0.01). Multiple stepwise regression analysis showed that HbA1C and BUN were influencing factors for serum CA19-9 levels (P < 0.05), and HbA1C and U-MA were influencing factors for serum CEA levels (P < 0.05).Conclusion: Both CA19-9 and CEA might be elevated at low levels in patients with T2DM; levels were closely correlated to the degree of glycemic control.Keywords: diabetes mellitus type 2, tumor marker, carbohydrate antigen 19-9, carcinoembryonic antigen, glycosylated hemoglobin, influencing factor
