Cytokines and cell adhesion molecules exhibit distinct profiles in health, ovarian cancer, and breast cancer

Abstract

Objective: We examined a panel of cytokines and cell adhesion molecules in an attempt to identify cancer specific profiles. Design and methods: Cytokines and cell adhesion arrays (Randox Ltd.) were measured in samples from women with a histological diagnosis of ovarian cancer (n=42) or breast cancer (n=60) or cancer free (n=32). Random forest analysis was used for classification. Results: Ovarian cancer subjects were classified with a sensitivity of 85.7% (95% CI 50–100) and a specificity of 84.2% (95% CI 69.4–93.4). Breast cancer subjects were classified with a sensitivity of 70.8% (95% CI 47.1–86.4) and a specificity of 96.4% (95% CI 82.1–100). Discussion: Cytokine and cell adhesion molecule profiles provide additional information that may be useful for cancer characterization of female cancers.

Keywords

• Statistics
• Laboratory medicine
• Medical informatics
• Cancer diagnostics