PLoS ONE (Jan 2021)

Intraoperative blood loss may be associated with myocardial injury after non-cardiac surgery.

  • Jungchan Park,
  • Ji-Hye Kwon,
  • Seung-Hwa Lee,
  • Jong Hwan Lee,
  • Jeong Jin Min,
  • Jihoon Kim,
  • Ah Ran Oh,
  • Wonho Seo,
  • Cheol Won Hyeon,
  • Kwangmo Yang,
  • Jin-Ho Choi,
  • Sang-Chol Lee,
  • Kyunga Kim,
  • Joonghyun Ahn,
  • Hyeon-Cheol Gwon

DOI
https://doi.org/10.1371/journal.pone.0241114
Journal volume & issue
Vol. 16, no. 2
p. e0241114

Abstract

Read online

BackgroundThis study aimed to evaluate the association between intraoperative blood loss and myocardial injury after non-cardiac surgery (MINS), which is a severe and common postoperative complication.MethodsWe compared the incidence of MINS based on significant intraoperative bleeding, defined as an absolute hemoglobin level ResultsWe stratified a total of 15,926 non-cardiac surgical patients with intraoperative hemoglobin and postoperative cardiac troponin (cTn) measurements according to the occurrence of significant intraoperative bleeding; 13,416 (84.2%) had no significant bleeding while 2,510 (15.8%) did have significant bleeding. After an adjustment with inverse probability weighting, the incidence of MINS was higher in the significant bleeding group (35.2% vs. 16.4%; odds ratio, 1.58; 95% confidence interval, 1.43-1.75; p ConclusionIntraoperative blood loss appeared to be associated with MINS. Further studies are needed to confirm these findings.Clinical registrationThe cohort was registered before patient enrollment at https://cris.nih.go.kr (KCT0004244).