NOS induction by NGF in basal forebrain cholinergic neurones: evidence for regulation of brain NOS by a neurotrophin

David M. Holtzman; Joshua Kilbridge; David S. Bredt; Stephen M. Black; Yiwen Li; Douglas O. Clary; Louis F. Reichardt; William C. Mobley

Neurobiology of Disease (Nov 1994)

NOS induction by NGF in basal forebrain cholinergic neurones: evidence for regulation of brain NOS by a neurotrophin

David M. Holtzman,
Joshua Kilbridge,
David S. Bredt,
Stephen M. Black,
Yiwen Li,
Douglas O. Clary,
Louis F. Reichardt,
William C. Mobley

Affiliations

David M. Holtzman: Department of Neurology, University of California, San Francisco, 505 Parnassus Ave, San Francisco, CA, 94143; Department of Pediatrics, University of California, San Francisco, 505 Parnassus Ave, San Francisco, CA, 94143; Department of Physiology, University of California, San Francisco, 505 Parnassus Ave, San Francisco, CA, 94143; Howard Hughes Medical Institute, University of California, San Francisco, 505 Parnassus Ave, San Francisco, CA, 94143; Neuroscience Program, University of California, San Francisco, 505 Parnassus Ave, San Francisco, CA, 94143
Joshua Kilbridge: Department of Neurology, University of California, San Francisco, 505 Parnassus Ave, San Francisco, CA, 94143; Department of Pediatrics, University of California, San Francisco, 505 Parnassus Ave, San Francisco, CA, 94143; Department of Physiology, University of California, San Francisco, 505 Parnassus Ave, San Francisco, CA, 94143; Howard Hughes Medical Institute, University of California, San Francisco, 505 Parnassus Ave, San Francisco, CA, 94143; Neuroscience Program, University of California, San Francisco, 505 Parnassus Ave, San Francisco, CA, 94143
David S. Bredt: Department of Neurology, University of California, San Francisco, 505 Parnassus Ave, San Francisco, CA, 94143; Department of Pediatrics, University of California, San Francisco, 505 Parnassus Ave, San Francisco, CA, 94143; Department of Physiology, University of California, San Francisco, 505 Parnassus Ave, San Francisco, CA, 94143; Howard Hughes Medical Institute, University of California, San Francisco, 505 Parnassus Ave, San Francisco, CA, 94143; Neuroscience Program, University of California, San Francisco, 505 Parnassus Ave, San Francisco, CA, 94143
Stephen M. Black: Department of Neurology, University of California, San Francisco, 505 Parnassus Ave, San Francisco, CA, 94143; Department of Pediatrics, University of California, San Francisco, 505 Parnassus Ave, San Francisco, CA, 94143; Department of Physiology, University of California, San Francisco, 505 Parnassus Ave, San Francisco, CA, 94143; Howard Hughes Medical Institute, University of California, San Francisco, 505 Parnassus Ave, San Francisco, CA, 94143; Neuroscience Program, University of California, San Francisco, 505 Parnassus Ave, San Francisco, CA, 94143
Yiwen Li: Department of Neurology, University of California, San Francisco, 505 Parnassus Ave, San Francisco, CA, 94143; Department of Pediatrics, University of California, San Francisco, 505 Parnassus Ave, San Francisco, CA, 94143; Department of Physiology, University of California, San Francisco, 505 Parnassus Ave, San Francisco, CA, 94143; Howard Hughes Medical Institute, University of California, San Francisco, 505 Parnassus Ave, San Francisco, CA, 94143; Neuroscience Program, University of California, San Francisco, 505 Parnassus Ave, San Francisco, CA, 94143
Douglas O. Clary: Department of Neurology, University of California, San Francisco, 505 Parnassus Ave, San Francisco, CA, 94143; Department of Pediatrics, University of California, San Francisco, 505 Parnassus Ave, San Francisco, CA, 94143; Department of Physiology, University of California, San Francisco, 505 Parnassus Ave, San Francisco, CA, 94143; Howard Hughes Medical Institute, University of California, San Francisco, 505 Parnassus Ave, San Francisco, CA, 94143; Neuroscience Program, University of California, San Francisco, 505 Parnassus Ave, San Francisco, CA, 94143
Louis F. Reichardt: Department of Neurology, University of California, San Francisco, 505 Parnassus Ave, San Francisco, CA, 94143; Department of Pediatrics, University of California, San Francisco, 505 Parnassus Ave, San Francisco, CA, 94143; Department of Physiology, University of California, San Francisco, 505 Parnassus Ave, San Francisco, CA, 94143; Howard Hughes Medical Institute, University of California, San Francisco, 505 Parnassus Ave, San Francisco, CA, 94143; Neuroscience Program, University of California, San Francisco, 505 Parnassus Ave, San Francisco, CA, 94143
William C. Mobley: Department of Neurology, University of California, San Francisco, 505 Parnassus Ave, San Francisco, CA, 94143; Department of Pediatrics, University of California, San Francisco, 505 Parnassus Ave, San Francisco, CA, 94143; Department of Physiology, University of California, San Francisco, 505 Parnassus Ave, San Francisco, CA, 94143; Howard Hughes Medical Institute, University of California, San Francisco, 505 Parnassus Ave, San Francisco, CA, 94143; Neuroscience Program, University of California, San Francisco, 505 Parnassus Ave, San Francisco, CA, 94143

Journal volume & issue: Vol. 1, no. 1
pp. 51 – 60

Abstract

Read online

Nerve growth factor (NGF) acts through trkA receptors to serve as a trophic factor for cholinergic neurones in the medial septal nucleus (MSN) and vertical limb of the diagonal band (VDB). Herein, we show that brain nitric oxide synthase (NOS), which synthesizes the neuromodulator nitric oxide, is selectively expressed in a large fraction of trkA-containing neurones in the MSN and VDB. Axotomy of these neurones gave evidence that NOS expressing cholinergic neurones innervate the hippocampus. NGF infusion induced a robust, specific increase in NOS expression in basal forebrain cholinergic neurones. These results indicate that brain NOS can be regulated by a neurotrophic factor and suggest that NGF influences forebrain function by regulating production of nitric oxide as well as acetylcholine.

Published in Neurobiology of Disease

ISSN: 0969-9961 (Print); 1095-953X (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Medicine: Internal medicine: Neurosciences. Biological psychiatry. Neuropsychiatry
Website: https://www.journals.elsevier.com/neurobiology-of-disease

About the journal

Abstract

Keywords