Impact of Prediabetes on Acute Coronary Syndrome in Sohag University Hospital

Abstract

Background: Diabetes mellitus is a known risk factor for cardiovascular disease. Diabetics with acute coronary syndrome (ACS) have a two- to four-fold higher chance of having unfavorable cardiovascular events than non-diabetics. It is becoming more and more obvious that poor glucose metabolism and the pre-diabetic condition are linked to unfavorable clinical results. Objectives: The current study aimed to assess the effects of prediabetes on acute coronary syndrome outcomes at Sohag University Hospital. Patients and methods; This was a prospective observational study carried out at Sohag University Hospital. Patients were divided into non-diabetic, prediabetic, and diabetic patients. All trial participants had thorough history-taking, clinical examinations, laboratory tests, and daily follow up (chest pain, ECG, blood pressure, fasting blood sugar, any sign of heart failure, or any complication occur). Results: This study involved 100 patients with ACS, 20 (20%) patients were non-diabetics, 27 (27%) were prediabetics, and 53 (53%) were diabetics. During follow-up, there was a higher nonsignificant rate of death in prediabetic patients (7.41%) than in diabetics (5.66%) and nondiabetic (5%) (p > 0.05). Also, the prediabetic group showed a higher nonsignificant abnormal change in ECG (81.48%) than the diabetic (81.13%) and nondiabetic (80.00%) (p > 0.05). Conclusion; In ACS, patients with normoglycemia had a better prognosis than those with prediabetes, but prediabetes and DM patients had comparable results.

Keywords

• prediabetes diabetes acute coronary syndrome outcome