Food Science & Nutrition (Apr 2021)

Antibacterial, anti‐inflammatory, analgesic, and hemostatic activities of Acanthopanax trifoliatus (L.) merr

  • Zefeng Chen,
  • Shupeng Cheng,
  • Huiqiong Lin,
  • Wenjing Wu,
  • Liyi Liang,
  • Xicai Chen,
  • Xi Zheng,
  • Yan He,
  • Kun Zhang

DOI
https://doi.org/10.1002/fsn3.2190
Journal volume & issue
Vol. 9, no. 4
pp. 2191 – 2202

Abstract

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Abstract Acanthopanax trifoliatus (L.) Merr (AT) is a medicinal and edible plant with high nutritional value. The biological activity of A. trifoliatus (L.) Merr and its basis for injury treatment are explored in this paper. AT was ethanol‐extracted then refined separately with petroleum ether, chloroform, ethyl acetate, and n‐butanol. Active ingredients were analyzed, and anti‐bacterial, anti‐inflammatory, analgesic, and hemostatic effects were explored. Petroleum ether layer (PEL) extract produced the strongest antibacterial effect. Ethyl acetate layer (EAL) extract had the highest active substance content, with strong hemostatic and analgesic activities. Chloroform layer (CL) extract had the strongest anti‐inflammatory effect and significantly reduced IL‐1β protein expression. Active ingredients were analyzed using HPLC and UPLC‐MS to determine saponin, polyphenol, flavonoid, and characteristic ingredient contents. EAL extract had the highest polyphenol and flavonoid levels, including rutin, chlorogenic acid, isochlorogenic acid A, and isochlorogenic acid C, which may contribute to its nutritional activities. The study provides a reliable theoretical and practical basis for the applications of AT nutraceutical products.

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