eJHaem (Nov 2022)

Lymphoplasmacytic lymphoma and marginal zone lymphoma involving bone marrow: A diagnostic dilemma. Useful clinicopathological features to accurate the diagnosis

  • Patricia García‐Abellás,
  • Ana Ferrer Gómez,
  • Diego Bueno Sacristán,
  • Miguel Piris Villaespesa,
  • María Talavera Yagüe,
  • María Eugenia Reguero Callejas,
  • Mónica García‐Cosío

DOI
https://doi.org/10.1002/jha2.573
Journal volume & issue
Vol. 3, no. 4
pp. 1181 – 1187

Abstract

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Abstract Lymphoplasmacytic lymphoma (LPL) and marginal zone lymphoma (MZL) frequently infiltrate the bone marrow with similar histologic and immunohistochemical characteristics posing diagnostic problems. Bone marrow biopsy specimens from 25 LPL and 16 MZL have been studied, correlating with clinical, laboratory parameters and the MYD88_p.L265P mutation. Paratrabecular and interstitial infiltration pattern, serum IgM paraprotein levels, and MYD88_p.L265P mutation were significantly more frequent in LPL. Nodular or intrasinusoidal pattern with lymphocytosis and splenomegaly were associated with MZL diagnosis. Different clinical and histological parameters should be collected when LPL or MZL is suspected in bone marrow biopsy specimens.

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