Communications Biology (Mar 2021)

A role for Dynlt3 in melanosome movement, distribution, acidity and transfer

  • Zackie Aktary,
  • Alejandro Conde-Perez,
  • Florian Rambow,
  • Mathilde Di Marco,
  • François Amblard,
  • Ilse Hurbain,
  • Graça Raposo,
  • Cédric Delevoye,
  • Sylvie Coscoy,
  • Lionel Larue

DOI
https://doi.org/10.1038/s42003-021-01917-5
Journal volume & issue
Vol. 4, no. 1
pp. 1 – 15

Abstract

Read online

Aktary et al. identify novel roles for the dynein light chain Dynlt3 in melanosome transport, maturation, and transfer to keratinocytes. They also find that the Wnt/βcatenin signalling pathway controls Dynlt3 levels and thus also contributes to the regulation of melanocyte transport and skin pigmentation.