Insights into Imaging (Dec 2023)

Predicting tumor deposits in rectal cancer: a combined deep learning model using T2-MR imaging and clinical features

  • Yumei Jin,
  • Hongkun Yin,
  • Huiling Zhang,
  • Yewu Wang,
  • Shengmei Liu,
  • Ling Yang,
  • Bin Song

DOI
https://doi.org/10.1186/s13244-023-01564-w
Journal volume & issue
Vol. 14, no. 1
pp. 1 – 13

Abstract

Read online

Abstract Background Tumor deposits (TDs) are associated with poor prognosis in rectal cancer (RC). This study aims to develop and validate a deep learning (DL) model incorporating T2-MR image and clinical factors for the preoperative prediction of TDs in RC patients. Methods and methods A total of 327 RC patients with pathologically confirmed TDs status from January 2016 to December 2019 were retrospectively recruited, and the T2-MR images and clinical variables were collected. Patients were randomly split into a development dataset (n = 246) and an independent testing dataset (n = 81). A single-channel DL model, a multi-channel DL model, a hybrid DL model, and a clinical model were constructed. The performance of these predictive models was assessed by using receiver operating characteristics (ROC) analysis and decision curve analysis (DCA). Results The areas under the curves (AUCs) of the clinical, single-DL, multi-DL, and hybrid-DL models were 0.734 (95% CI, 0.674–0.788), 0.710 (95% CI, 0.649–0.766), 0.767 (95% CI, 0.710–0.819), and 0.857 (95% CI, 0.807–0.898) in the development dataset. The AUC of the hybrid-DL model was significantly higher than the single-DL and multi-DL models (both p < 0.001) in the development dataset, and the single-DL model (p = 0.028) in the testing dataset. Decision curve analysis demonstrated the hybrid-DL model had higher net benefit than other models across the majority range of threshold probabilities. Conclusions The proposed hybrid-DL model achieved good predictive efficacy and could be used to predict tumor deposits in rectal cancer. Critical relevance statement The proposed hybrid-DL model achieved good predictive efficacy and could be used to predict tumor deposits in rectal cancer. Key points • Preoperative non-invasive identification of TDs is of great clinical significance. • The combined hybrid-DL model achieved good predictive efficacy and could be used to predict tumor deposits in rectal cancer. • A preoperative nomogram provides gastroenterologist with an accurate and effective tool. Graphical Abstract

Keywords