Journal of Clinical Medicine (Aug 2020)
Correlation of Arterial CO<sub>2</sub> and Respiratory Impedance Values among Subjects with COPD
- Tomoki Uno,
- Tetsuya Homma,
- Masahiko Shigemura,
- Yosuke Fukuda,
- Tomoyuki Kimura,
- Chihiro Onitsuka,
- Tomoko Kawahara,
- Hiroki Sato,
- Kaho Akimoto,
- Hiromitsu Suganuma,
- Ayaka Kashima,
- Shigenori Yamamoto,
- Takaya Ebato,
- Tomohiro Matsunaga,
- Keisuke Kaneko,
- Hatsuko Mikuni,
- Haruna Sato,
- Yoshitaka Uchida,
- Akiko Fujiwara,
- Naota Kuwahara,
- Ryo Manabe,
- Hitomi Ida,
- Kuniaki Hirai,
- Yoshito Miyata,
- Megumi Jinno,
- Shin Ohta,
- Yasunari Kishino,
- Hideki Inoue,
- Mayumi Yamamoto,
- Yoshio Watanabe,
- Sojiro Kusumoto,
- Koichi Ando,
- Shintaro Suzuki,
- Akihiko Tanaka,
- Tohru Ohmori,
- Hironori Sagara
Affiliations
- Tomoki Uno
- Department of Medicine, Division of Respiratory Medicine and Allergology, 1-5-8 Hatanodai, Shinagawa-ku, Showa University School of Medicine, Tokyo 142-0064, Japan
- Tetsuya Homma
- Department of Medicine, Division of Respiratory Medicine and Allergology, 1-5-8 Hatanodai, Shinagawa-ku, Showa University School of Medicine, Tokyo 142-0064, Japan
- Masahiko Shigemura
- Division of Pulmonary and Critical Care Medicine, Northwestern University, Chicago, IL 60611, USA
- Yosuke Fukuda
- Department of Medicine, Division of Respiratory Medicine and Allergology, 1-5-8 Hatanodai, Shinagawa-ku, Showa University School of Medicine, Tokyo 142-0064, Japan
- Tomoyuki Kimura
- Department of Medicine, Division of Respiratory Medicine and Allergology, 1-5-8 Hatanodai, Shinagawa-ku, Showa University School of Medicine, Tokyo 142-0064, Japan
- Chihiro Onitsuka
- Department of Medicine, Division of Respiratory Medicine and Allergology, 1-5-8 Hatanodai, Shinagawa-ku, Showa University School of Medicine, Tokyo 142-0064, Japan
- Tomoko Kawahara
- Department of Medicine, Division of Respiratory Medicine and Allergology, 1-5-8 Hatanodai, Shinagawa-ku, Showa University School of Medicine, Tokyo 142-0064, Japan
- Hiroki Sato
- Department of Medicine, Division of Respiratory Medicine and Allergology, 1-5-8 Hatanodai, Shinagawa-ku, Showa University School of Medicine, Tokyo 142-0064, Japan
- Kaho Akimoto
- Department of Medicine, Division of Respiratory Medicine and Allergology, 1-5-8 Hatanodai, Shinagawa-ku, Showa University School of Medicine, Tokyo 142-0064, Japan
- Hiromitsu Suganuma
- Department of Respiratory Medicine, Asahi General Hospital, Chiba 289-2511, Japan
- Ayaka Kashima
- Department of Respiratory Medicine, Asahi General Hospital, Chiba 289-2511, Japan
- Shigenori Yamamoto
- Department of Pulmonary Medicine, Tokyo Metropolitan Health and Hospitals Corporation Ebara Hospital, Tokyo 145-0065, Japan
- Takaya Ebato
- Department of Respiratory Medicine, Yamanashi Red Cross Hospital, Yamanashi 401-0301, Japan
- Tomohiro Matsunaga
- Department of Medicine, Division of Allergology and Respiratory Medicine, Showa University Koto Toyosu Hospital, Tokyo 135-8577, Japan
- Keisuke Kaneko
- Department of Respiratory Medicine, Ibarakihigashi National Hospital, Ibaraki 142-0064, Japan
- Hatsuko Mikuni
- Department of Medicine, Division of Respiratory Medicine and Allergology, 1-5-8 Hatanodai, Shinagawa-ku, Showa University School of Medicine, Tokyo 142-0064, Japan
- Haruna Sato
- Department of Medicine, Division of Respiratory Medicine and Allergology, 1-5-8 Hatanodai, Shinagawa-ku, Showa University School of Medicine, Tokyo 142-0064, Japan
- Yoshitaka Uchida
- Department of Medicine, Division of Respiratory Medicine and Allergology, 1-5-8 Hatanodai, Shinagawa-ku, Showa University School of Medicine, Tokyo 142-0064, Japan
- Akiko Fujiwara
- Respiratory Disease Center, Showa University Northern Yokohama Hospital, Kanagawa 224-8503, Japan
- Naota Kuwahara
- Department of Medicine, Division of Allergology and Respiratory Medicine, Showa University Koto Toyosu Hospital, Tokyo 135-8577, Japan
- Ryo Manabe
- Department of Medicine, Division of Allergology and Respiratory Medicine, Showa University Koto Toyosu Hospital, Tokyo 135-8577, Japan
- Hitomi Ida
- Department of Medicine, Division of Allergology and Respiratory Medicine, Showa University Koto Toyosu Hospital, Tokyo 135-8577, Japan
- Kuniaki Hirai
- Department of Medicine, Division of Respiratory Medicine and Allergology, 1-5-8 Hatanodai, Shinagawa-ku, Showa University School of Medicine, Tokyo 142-0064, Japan
- Yoshito Miyata
- Department of Medicine, Division of Respiratory Medicine and Allergology, 1-5-8 Hatanodai, Shinagawa-ku, Showa University School of Medicine, Tokyo 142-0064, Japan
- Megumi Jinno
- Department of Medicine, Division of Respiratory Medicine and Allergology, 1-5-8 Hatanodai, Shinagawa-ku, Showa University School of Medicine, Tokyo 142-0064, Japan
- Shin Ohta
- Department of Medicine, Division of Respiratory Medicine and Allergology, 1-5-8 Hatanodai, Shinagawa-ku, Showa University School of Medicine, Tokyo 142-0064, Japan
- Yasunari Kishino
- Department of Medicine, Division of Respiratory Medicine and Allergology, 1-5-8 Hatanodai, Shinagawa-ku, Showa University School of Medicine, Tokyo 142-0064, Japan
- Hideki Inoue
- Department of Medicine, Division of Respiratory Medicine and Allergology, 1-5-8 Hatanodai, Shinagawa-ku, Showa University School of Medicine, Tokyo 142-0064, Japan
- Mayumi Yamamoto
- Department of Medicine, Division of Respiratory Medicine and Allergology, 1-5-8 Hatanodai, Shinagawa-ku, Showa University School of Medicine, Tokyo 142-0064, Japan
- Yoshio Watanabe
- Department of Medicine, Division of Respiratory Medicine and Allergology, 1-5-8 Hatanodai, Shinagawa-ku, Showa University School of Medicine, Tokyo 142-0064, Japan
- Sojiro Kusumoto
- Department of Medicine, Division of Respiratory Medicine and Allergology, 1-5-8 Hatanodai, Shinagawa-ku, Showa University School of Medicine, Tokyo 142-0064, Japan
- Koichi Ando
- Department of Medicine, Division of Respiratory Medicine and Allergology, 1-5-8 Hatanodai, Shinagawa-ku, Showa University School of Medicine, Tokyo 142-0064, Japan
- Shintaro Suzuki
- Department of Medicine, Division of Respiratory Medicine and Allergology, 1-5-8 Hatanodai, Shinagawa-ku, Showa University School of Medicine, Tokyo 142-0064, Japan
- Akihiko Tanaka
- Department of Medicine, Division of Respiratory Medicine and Allergology, 1-5-8 Hatanodai, Shinagawa-ku, Showa University School of Medicine, Tokyo 142-0064, Japan
- Tohru Ohmori
- Department of Medicine, Division of Respiratory Medicine and Allergology, 1-5-8 Hatanodai, Shinagawa-ku, Showa University School of Medicine, Tokyo 142-0064, Japan
- Hironori Sagara
- Department of Medicine, Division of Respiratory Medicine and Allergology, 1-5-8 Hatanodai, Shinagawa-ku, Showa University School of Medicine, Tokyo 142-0064, Japan
- DOI
- https://doi.org/10.3390/jcm9092819
- Journal volume & issue
-
Vol. 9,
no. 9
p. 2819
Abstract
Chronic obstructive pulmonary disease (COPD) is a respiratory illness characterized by airflow limitation and chronic respiratory symptoms with a global prevalence estimated to be more than 10% in 2010 and still on the rise. Furthermore, hypercapnic subject COPD leads to an increased risk of mortality, morbidity, and poor QoL (quality of life) than normocapnic subjects. Series of studies showed the usefulness of the forced oscillation technique (FOT) to measure small airway closure. Traditional findings suggested that hypercapnia may not be the main treating targets, but recent findings suggested that blood stream CO2 may lead to a worse outcome. This study aimed to seek the relationship between CO2 and small airway closure by using FOT. Subjects with COPD (n = 124; hypercapnia 22 and normocapnia 102) were analyzed for all pulmonary function values, FOT values, and arterial blood gas analysis. Student’s t-test, Spearman rank correlation, and multi linear regression analysis were used to analyze the data. COPD subjects with hypercapnia showed a significant increase in R5, R20, Fres, and ALX values, and a greater decrease in X5 value than normocapnic patients. Also, multiple linear regression analysis showed R5 was associated with hypercapnia. Hypercapnia may account for airway closure among subjects with COPD and this result suggests treating hypercapnia may lead to better outcomes for such a subject group.
Keywords