Therapeutics and Clinical Risk Management (Aug 2021)
Association Analysis of Insulin Resistance and Osteoporosis Risk in Chinese Patients with T2DM
Abstract
Xinshui Wang,1 Lijuan Jiang,2 Xiaonan Shao3 1Department of Endocrinology, The Third Affiliated Hospital of Soochow University, Changzhou, 213003, People’s Republic of China; 2Department of Clinical Laboratory, The Third Affiliated Hospital of Soochow University, Changzhou, 213003, People’s Republic of China; 3Department of Nuclear Medicine, The Third Affiliated Hospital of Soochow University, Changzhou, 213003, People’s Republic of ChinaCorrespondence: Lijuan JiangDepartment of Clinical Laboratory, the Third Affiliated Hospital of Soochow University, Changzhou, 213003, People’s Republic of ChinaTel +86-0-13776885831Fax +86-0519-86621235Email [email protected]: To explore the relationship between insulin resistance and osteoporosis risk in Chinese patients with type 2 diabetes mellitus (T2DM).Methods: A total of 234 T2DM patients were retrospectively analyzed, and their lumbar bone mineral density (BMD) and insulin resistance using C-peptide-based homeostasis model of insulin resistance [HOMA-IR (CP)] were assessed. Univariate and multivariable logistic regression methods were used to evaluate the association between HOMA-IR (CP) and osteoporosis, and subgroup analysis was performed on female and male patients.Results: After fully adjusting the covariates, the association between HOMA-IR (CP) and osteoporosis was only significant in female patients (P = 0.022); the interaction effect with gender was significant (P for interaction 4.00, the risk of osteoporosis increased significantly, with OR = 26.88 (95% CI: 2.75– 262.69, P = 0.005). The relationship between insulin resistance and osteoporosis risk in T2DM patients is significantly affected by gender.Conclusion: The higher the degree of insulin resistance in female patients, the greater the risk of osteoporosis, but the two are not linearly associated.Keywords: type 2 diabetes mellitus, insulin resistance, osteoporosis, bone mineral density, homeostasis model assessment for insulin resistance
