Blood Science (Oct 2021)

The correlation between Flt3-ITD mutation in dendritic cells with TIM-3 expression in acute myeloid leukemia

  • Hooriyeh Shapoorian,
  • Hamidreza Zalpoor,
  • Mazdak Ganjalikhani-Hakemi

DOI
https://doi.org/10.1097/BS9.0000000000000092
Journal volume & issue
Vol. 3, no. 4
pp. 132 – 135

Abstract

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Abstract. In general, acute myeloid leukemia (AML) is an aggressive and heterogeneous disease that is characterized by rapid cellular proliferation and high mortality. One of the mutations related to AML is the Flt3-ITD mutation, which is found in approximately 25% of patients. In this mini-review, we investigate the function of dendritic cells and T cells based on Flt3-ITD mutation and immune evasion as a result of this abnormality. Finally, we discuss some AML therapeutic strategies, including targeting Flt3 on DCs and TIM-3 on T cells as immune receptors to treat this hematopoietic malignancy.