Higher versus Lower Oxygen Concentration during Respiratory Support in the Delivery Room in Extremely Preterm Infants: A Pilot Feasibility Study
Brenda Hiu Yan Law,
Elizabeth Asztalos,
Neil N. Finer,
Maryna Yaskina,
Maximo Vento,
William Tarnow-Mordi,
Prakesh S. Shah,
Georg M. Schmölzer
Affiliations
Brenda Hiu Yan Law
Centre for the Studies of Asphyxia and Resuscitation, Neonatal Research Unit, Royal Alexandra Hospital, Alberta Health Services, Edmonton, AB T5H 3V9, Canada
Elizabeth Asztalos
Sunnybrook Health Sciences Centre, Department of Paediatrics, University of Toronto, Toronto, ON M4N 3M5, Canada
Neil N. Finer
School of Medicine, University of California, San Diego, CA 92093, USA
Maryna Yaskina
Women and Children’s Health Research Institute, Department of Pediatrics, University of Alberta, Edmonton, AB T6G 1C9, Canada
Maximo Vento
Health Research Centre, University and Polytechnic Hospital La Fe, 46026 Valencia, Spain
William Tarnow-Mordi
NHMRC Clinical Trials Centre, University of Sydney, Camperdown, NSW 2050, Australia
Prakesh S. Shah
Department of Pediatrics, Mount Sinai Hospital, University of Toronto, Toronto, ON M5G 1X5, Canada
Georg M. Schmölzer
Centre for the Studies of Asphyxia and Resuscitation, Neonatal Research Unit, Royal Alexandra Hospital, Alberta Health Services, Edmonton, AB T5H 3V9, Canada
Background: Optimal starting oxygen concentration for delivery room resuscitation of extremely preterm infants (50%. Results: Thirty-four infants were born during a 4-month period; consent was obtained in 63%. Thirty (n = 12, 30% group; n = 18, 60% group) were analyzed, including limited data from eight who died or were transferred before parents could be approached. Median cumulative oxygen concentrations were significantly different between the two groups in the first 5 min. Conclusion: Randomized control trial of 30% or 60% oxygen at the initiation of resuscitation of extremely preterm neonates with deferred consent is feasible. Trial registration: Clinicaltrials.gov NCT03706586
