Synthetic studies towards bottromycin

Abstract

Thio-Ugi reactions are described as an excellent synthetic tool for the synthesis of sterically highly hindered endothiopeptides. S-Methylation and subsequent amidine formation can be carried out in an inter- as well as in an intramolecular fashion. The intramolecular approach allows the synthesis of the bottromycin ring system in a straightforward manner.

Keywords

• amidines
• antibiotics
• bottromycin
• peptides
• thiopeptides
• Ugi reactions