PROVE—Pre-Eclampsia Obstetric Adverse Events: Establishment of a Biobank and Database for Pre-Eclampsia
Lina Bergman,
Karl Bergman,
Eduard Langenegger,
Ashley Moodley,
Stephanie Griffith-Richards,
Johan Wikström,
David Hall,
Lloyd Joubert,
Philip Herbst,
Sonja Schell,
Teelkien van Veen,
Michael Belfort,
Stephen Y. C. Tong,
Susan Walker,
Roxanne Hastie,
Catherine Cluver
Affiliations
Lina Bergman
Department of Women’s and Children’s Health, Uppsala University, 75309 Uppsala, Sweden
Karl Bergman
Department of Molecular and Clinical Medicine, Institution of Medicine, Sahlgrenska Academy, University of Gothenburg, 41650 Gothenburg, Sweden
Eduard Langenegger
Department of Obstetrics and Gynaecology, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town 7505, South Africa
Ashley Moodley
Department of Obstetrics and Gynaecology, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town 7505, South Africa
Stephanie Griffith-Richards
Division of Radiodiagnosis, Department of Medical Imaging and Clinical Oncology, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town 7505, South Africa
Johan Wikström
Department of Surgical Sciences, Radiology, Uppsala University, 75309 Uppsala, Sweden
David Hall
Department of Obstetrics and Gynaecology, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town 7505, South Africa
Lloyd Joubert
Division of Cardiology, Department of Medicine, Medicine and Health Sciences, Stellenbosch University, Cape Town 7505, South Africa
Philip Herbst
Department of Obstetrics and Gynaecology, University Medical Center Groningen, 9713 Groningen, The Netherlands
Sonja Schell
Department of Obstetrics and Gynaecology, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town 7505, South Africa
Teelkien van Veen
Department of Obstetrics and Gynaecology, University Medical Center Groningen, 9713 Groningen, The Netherlands
Michael Belfort
Department of Obstetrics and Gynaecology, Baylor College of Medicine, Houston, TX 77004, USA
Stephen Y. C. Tong
Translational Obstetrics Group, Department of Obstetrics and Gynaecology, University of Melbourne, Parkville, VIC 3010, Australia
Susan Walker
Translational Obstetrics Group, Department of Obstetrics and Gynaecology, University of Melbourne, Parkville, VIC 3010, Australia
Roxanne Hastie
Translational Obstetrics Group, Department of Obstetrics and Gynaecology, University of Melbourne, Parkville, VIC 3010, Australia
Catherine Cluver
Department of Obstetrics and Gynaecology, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town 7505, South Africa
Pre-eclampsia is a leading cause of maternal and perinatal morbidity and mortality. The burden of disease lies mainly in low-middle income countries. The aim of this project is to establish a pre-eclampsia biobank in South Africa to facilitate research in the field of pre-eclampsia with a focus on phenotyping severe disease.The approach of our biobank is to collect biological specimens, detailed clinical data, tests, and biophysical examinations, including magnetic resonance imaging (MRI) of the brain, MRI of the heart, transcranial Doppler, echocardiography, and cognitive function tests.Women diagnosed with pre-eclampsia and normotensive controls are enrolled in the biobank at admission to Tygerberg University Hospital (Cape Town, South Africa). Biological samples and clinical data are collected at inclusion/delivery and during the hospital stay. Special investigations as per above are performed in a subset of women. After two months, women are followed up by telephonic interviews. This project aims to establish a biobank and database for severe organ complications of pre-eclampsia in a low-middle income country where the incidence of pre-eclampsia with organ complications is high. The study integrates different methods to investigate pre-eclampsia, focusing on improved understanding of pathophysiology, prediction of organ complications, and potentially future drug evaluation and discovery.
