Is the IL1RA/IL1B Ratio a Suitable Biomarker for Subclinical Endometritis in Dairy Cows?
Anna Maria Kneidl,
Christina Deborah Marth,
Sandra Kirsch,
Frank Weber,
Yury Zablotski,
Anika Luzia Helfrich,
Simone Tamara Schabmeyer,
Julia Katharina Schneider,
Wolfram Petzl,
Holm Zerbe,
Marie Margarete Meyerholz-Wohllebe
Affiliations
Anna Maria Kneidl
Clinic for Ruminants with Ambulatory and Herd Health Services, Centre for Clinical Veterinary Medicine, Ludwig Maximilian University Munich, 85764 Oberschleissheim, Germany
Christina Deborah Marth
Melbourne Veterinary School, Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, Werribee, VIC 3030, Australia
Sandra Kirsch
Clinic for Ruminants with Ambulatory and Herd Health Services, Centre for Clinical Veterinary Medicine, Ludwig Maximilian University Munich, 85764 Oberschleissheim, Germany
Frank Weber
Clinic for Ruminants with Ambulatory and Herd Health Services, Centre for Clinical Veterinary Medicine, Ludwig Maximilian University Munich, 85764 Oberschleissheim, Germany
Yury Zablotski
Clinic for Ruminants with Ambulatory and Herd Health Services, Centre for Clinical Veterinary Medicine, Ludwig Maximilian University Munich, 85764 Oberschleissheim, Germany
Anika Luzia Helfrich
Clinic for Ruminants with Ambulatory and Herd Health Services, Centre for Clinical Veterinary Medicine, Ludwig Maximilian University Munich, 85764 Oberschleissheim, Germany
Simone Tamara Schabmeyer
Clinic for Ruminants with Ambulatory and Herd Health Services, Centre for Clinical Veterinary Medicine, Ludwig Maximilian University Munich, 85764 Oberschleissheim, Germany
Julia Katharina Schneider
Clinic for Ruminants with Ambulatory and Herd Health Services, Centre for Clinical Veterinary Medicine, Ludwig Maximilian University Munich, 85764 Oberschleissheim, Germany
Wolfram Petzl
Clinic for Ruminants with Ambulatory and Herd Health Services, Centre for Clinical Veterinary Medicine, Ludwig Maximilian University Munich, 85764 Oberschleissheim, Germany
Holm Zerbe
Clinic for Ruminants with Ambulatory and Herd Health Services, Centre for Clinical Veterinary Medicine, Ludwig Maximilian University Munich, 85764 Oberschleissheim, Germany
Marie Margarete Meyerholz-Wohllebe
Clinic for Ruminants with Ambulatory and Herd Health Services, Centre for Clinical Veterinary Medicine, Ludwig Maximilian University Munich, 85764 Oberschleissheim, Germany
The adequate expression of cytokines is essential for the prevention and healing of bovine endometrial inflammation. This study investigated the intra-uterine concentration of the proinflammatory cytokine interleukin (IL)1B and its antagonist IL1RA in cows with and without subclinical endometritis (SE). Samples were taken from 37 uteri at the abattoir and 26 uteri in vivo. Uterine secretion samples were classified as showing no signs of SE (SEneg; polymorphonuclear neutrophil granulocyte (PMN) p = 0.027; in vivo p p > 0.05). In uterine secretion samples retrieved in vivo, a lower IL1RA/IL1B ratio was detected in the SEpos group compared with the SEneg group (p = 0.002). The results of this study highlight the important role of IL1B and IL1RA during endometritis and the potential of the IL1RA/IL1B ratio as a possible biomarker for SE.
