Molbank (Aug 2024)

3-((2-(4-Chloro-5-ethoxy-2-nitrophenoxy)acetamido)methyl)phenyl-dimethylcarbamate

  • Rosalba Leuci,
  • Daniela Dininno,
  • Marco Paparella,
  • Luca Piemontese

DOI
https://doi.org/10.3390/M1863
Journal volume & issue
Vol. 2024, no. 3
p. M1863

Abstract

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In this study, we report the synthesis of 3-((2-(4-chloro-5-ethoxy-2-nitrophenoxy)acetamido)methyl)phenyl-dimethylcarbamate, designed on the basis of the structures of the commercial acetylcholinesterase inhibitor drug rivastigmine and a substituted aryloxyacetic acid, aiming at a multi-target approach to the therapy of Alzheimer’s disease. The hybrid was obtained thanks to a synthesized intermediate by-product. The compound was fully characterized by using 1H and 13C NMR, FT-IR and HRMS.

Keywords