Cyclodextrin–polysaccharide-based, in situ-gelled system for ocular antifungal delivery

Anxo Fernández-Ferreiro; Noelia Fernández Bargiela; María Santiago Varela; Maria Gil Martínez; Maria Pardo; Antonio Piñeiro Ces; José Blanco Méndez; Miguel González Barcia; Maria Jesus Lamas; Francisco.J. Otero-Espinar

doi:10.3762/bjoc.10.308

Beilstein Journal of Organic Chemistry (Dec 2014)

Cyclodextrin–polysaccharide-based, in situ-gelled system for ocular antifungal delivery

Anxo Fernández-Ferreiro,
Noelia Fernández Bargiela,
María Santiago Varela,
Maria Gil Martínez,
Maria Pardo,
Antonio Piñeiro Ces,
José Blanco Méndez,
Miguel González Barcia,
Maria Jesus Lamas,
Francisco.J. Otero-Espinar

Affiliations

Anxo Fernández-Ferreiro: Pharmacy and Pharmaceutical Technology Department, Faculty of Pharmacy, University of Santiago de Compostela (USC), Praza Seminario de Estudos Galegos s/n, Santiago de Compostela, 1570, Spain
Noelia Fernández Bargiela: Pharmacy and Pharmaceutical Technology Department, Faculty of Pharmacy, University of Santiago de Compostela (USC), Praza Seminario de Estudos Galegos s/n, Santiago de Compostela, 1570, Spain
María Santiago Varela: Ophthalmology Department, Hospital de Conxo, Xerencia de Xestión Integrada de Santiago de Compostela, SERGAS, Rua Ramón Baltar s/n, Santiago de Compostela, 15706, Spain
Maria Gil Martínez: Ophthalmology Department, Hospital de Conxo, Xerencia de Xestión Integrada de Santiago de Compostela, SERGAS, Rua Ramón Baltar s/n, Santiago de Compostela, 15706, Spain
Maria Pardo: Grupo Obesidomica, Instituto de Investigación Sanitaria (IDIS-ISCIII), SERGAS, Travesía da Choupana s/n, Santiago de Compostela, 15706, Spain
Antonio Piñeiro Ces: Ophthalmology Department, Hospital de Conxo, Xerencia de Xestión Integrada de Santiago de Compostela, SERGAS, Rua Ramón Baltar s/n, Santiago de Compostela, 15706, Spain
José Blanco Méndez: Pharmacy and Pharmaceutical Technology Department, Faculty of Pharmacy, University of Santiago de Compostela (USC), Praza Seminario de Estudos Galegos s/n, Santiago de Compostela, 1570, Spain
Miguel González Barcia: Pharmacy Department, Xerencia de Xestión Integrada de Santiago de Compostela, SERGAS, Travesía Choupana s/n, Santiago de Compostela, 15706, Spain
Maria Jesus Lamas: Pharmacy Department, Xerencia de Xestión Integrada de Santiago de Compostela, SERGAS, Travesía Choupana s/n, Santiago de Compostela, 15706, Spain
Francisco.J. Otero-Espinar: Pharmacy and Pharmaceutical Technology Department, Faculty of Pharmacy, University of Santiago de Compostela (USC), Praza Seminario de Estudos Galegos s/n, Santiago de Compostela, 1570, Spain

DOI: https://doi.org/10.3762/bjoc.10.308
Journal volume & issue: Vol. 10, no. 1
pp. 2903 – 2911

Abstract

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Fluconazole was studied with two different hydrophilic cyclodextrins (hydroxypropyl-β-cyclodextrin (HPBCD) and sulfobutyl ether-β-cyclodextrin (SBECD)) for the formation of inclusion complexes. HPBCD and SBECD showed low cell cytotoxicity in human keratocytes as assessed by the label-free xCELLigence system for real-time monitoring. The fluconazole–HPBCD complex was incorporated into an ion-sensitive ophthalmic gel composed of the natural polysaccharides gellan gum and κ-carrageenan. This system showed good bioadhesive properties and effective control of fluconazole release.

Published in Beilstein Journal of Organic Chemistry

ISSN: 1860-5397 (Online)
Publisher: Beilstein-Institut
Country of publisher: Germany
LCC subjects: Science: Chemistry: Organic chemistry
Website: http://www.beilstein-journals.org/bjoc

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