Nature Communications (Dec 2017)

Human CD26high T cells elicit tumor immunity against multiple malignancies via enhanced migration and persistence

  • Stefanie R. Bailey,
  • Michelle H. Nelson,
  • Kinga Majchrzak,
  • Jacob S. Bowers,
  • Megan M. Wyatt,
  • Aubrey S. Smith,
  • Lillian R. Neal,
  • Keisuke Shirai,
  • Carmine Carpenito,
  • Carl H. June,
  • Michael J. Zilliox,
  • Chrystal M. Paulos

DOI
https://doi.org/10.1038/s41467-017-01867-9
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 13

Abstract

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The role of human CD4+ T cell subsets in cancer immunotherapy is still unclear. Here, the authors show that CD26 identifies three CD4+ T cell subsets with distinct immunological properties in both healthy individuals and cancer patients.