Iraqi Journal of Pharmaceutical Sciences (Jun 2019)

Synthesis and Characterization of New Etodolac Derivatives with Possible Anti-Inflammatory Activity

  • Omeed Muhsin Hassan,
  • Susan Sarsam

DOI
https://doi.org/10.31351/vol28iss1pp107-113
Journal volume & issue
Vol. 28, no. 1
pp. 107 – 113

Abstract

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A series of Etodolac hydrazone derivatives were synthesized and evaluated for their anti-inflammatory activity by using egg white induced paw edema method. All the synthesized target compounds were characterized by CHN- microanalysis, FT-IR spectroscopy and 1HNMR analysis. The synthesized target compounds (P1-P3) were found to be active in reducing paw edema thickness and their anti-inflammatory effect was comparable to that of the standard (Etodolac). Keywords: Etodolac hydrazone derivatives, anti-inflammatory, paw edemamethod.

Keywords