Exosomes in the Tumor Microenvironment: From Biology to Clinical Applications

Vitor Rodrigues da Costa; Rodrigo Pinheiro Araldi; Hugo Vigerelli; Fernanda D’Ámelio; Thais Biude Mendes; Vivian Gonzaga; Bruna Policíquio; Gabriel Avelar Colozza-Gama; Cristiane Wenceslau Valverde; Irina Kerkis

doi:10.3390/cells10102617

Cells (Oct 2021)

Exosomes in the Tumor Microenvironment: From Biology to Clinical Applications

Vitor Rodrigues da Costa,
Rodrigo Pinheiro Araldi,
Hugo Vigerelli,
Fernanda D’Ámelio,
Thais Biude Mendes,
Vivian Gonzaga,
Bruna Policíquio,
Gabriel Avelar Colozza-Gama,
Cristiane Wenceslau Valverde,
Irina Kerkis

Affiliations

Vitor Rodrigues da Costa: Programa de Pós-Graduação em Biologia Estrutural e Funcional, Escola Paulista de Medicina (EPM), Federal University of São Paulo (UNIFES), São Paulo 04039-032, Brazil
Rodrigo Pinheiro Araldi: Programa de Pós-Graduação em Biologia Estrutural e Funcional, Escola Paulista de Medicina (EPM), Federal University of São Paulo (UNIFES), São Paulo 04039-032, Brazil
Hugo Vigerelli: Genetics Laboratory, Instituto Butantan, São Paulo 05508-010, Brazil
Fernanda D’Ámelio: Genetics Laboratory, Instituto Butantan, São Paulo 05508-010, Brazil
Thais Biude Mendes: Programa de Pós-Graduação em Biologia Estrutural e Funcional, Escola Paulista de Medicina (EPM), Federal University of São Paulo (UNIFES), São Paulo 04039-032, Brazil
Vivian Gonzaga: Genetics Laboratory, Instituto Butantan, São Paulo 05508-010, Brazil
Bruna Policíquio: Genetics Laboratory, Instituto Butantan, São Paulo 05508-010, Brazil
Gabriel Avelar Colozza-Gama: Programa de Pós-Graduação em Biologia Estrutural e Funcional, Escola Paulista de Medicina (EPM), Federal University of São Paulo (UNIFES), São Paulo 04039-032, Brazil
Cristiane Wenceslau Valverde: Cellavita Pesquisas Científicas Ltd.a., Valinhos 13271-650, Brazil
Irina Kerkis: Programa de Pós-Graduação em Biologia Estrutural e Funcional, Escola Paulista de Medicina (EPM), Federal University of São Paulo (UNIFES), São Paulo 04039-032, Brazil

DOI: https://doi.org/10.3390/cells10102617
Journal volume & issue: Vol. 10, no. 10
p. 2617

Abstract

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Cancer is one of the most important health problems and the second leading cause of death worldwide. Despite the advances in oncology, cancer heterogeneity remains challenging to therapeutics. This is because the exosome-mediated crosstalk between cancer and non-cancer cells within the tumor microenvironment (TME) contributes to the acquisition of all hallmarks of cancer and leads to the formation of cancer stem cells (CSCs), which exhibit resistance to a range of anticancer drugs. Thus, this review aims to summarize the role of TME-derived exosomes in cancer biology and explore the clinical potential of mesenchymal stem-cell-derived exosomes as a cancer treatment, discussing future prospects of cell-free therapy for cancer treatment and challenges to be overcome.

Published in Cells

ISSN: 2073-4409 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Biology (General): Cytology
Website: https://www.mdpi.com/journal/cells

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