A prospective multicenter study on varicella-zoster virus infection in children with acute lymphoblastic leukemia

Peifang Xiao; Jiaoyang Cai; Ju Gao; Wei Gao; Xianmin Guan; Alex Wing Kwan Leung; Yiying He; Yong Zhuang; Jinhua Chu; Xiaowen Zhai; Benquan Qi; Aiguo Liu; Liangchun Yang; Jiashi Zhu; Zheng Li; Xin Tian; Yao Xue; Li Hao; Xuedong Wu; Fen Zhou; Lingzhen Wang; Jingyan Tang; Shuhong Shen; Shaoyan Hu

doi:10.3389/fcimb.2022.981220

Frontiers in Cellular and Infection Microbiology (Nov 2022)

A prospective multicenter study on varicella-zoster virus infection in children with acute lymphoblastic leukemia

Peifang Xiao,
Jiaoyang Cai,
Ju Gao,
Wei Gao,
Xianmin Guan,
Alex Wing Kwan Leung,
Yiying He,
Yong Zhuang,
Jinhua Chu,
Xiaowen Zhai,
Benquan Qi,
Aiguo Liu,
Liangchun Yang,
Jiashi Zhu,
Zheng Li,
Xin Tian,
Yao Xue,
Li Hao,
Xuedong Wu,
Fen Zhou,
Lingzhen Wang,
Jingyan Tang,
Shuhong Shen,
Shaoyan Hu

Affiliations

Peifang Xiao: Department of Hematology, Jiangsu Children Hematology and Oncology Center Children’s Hospital of Soochow University, Suzhou, China
Jiaoyang Cai: Department of Hematology/Oncology, Shanghai Children’s Medical Center, School of Medicine, Shanghai Jiao Tong University, National Health Committee Key Laboratory of Pediatric Hematology and Oncology, Shanghai, China
Ju Gao: Department of Pediatrics, West China Second University Hospital, Sichuan University, Key Laboratory of Birth Defects and Related Disease of Women and Children, Ministry of Education, Chengdu, China
Wei Gao: Department of Hematology, Jiangsu Children Hematology and Oncology Center Children’s Hospital of Soochow University, Suzhou, China
Xianmin Guan: Department of Hematology/Oncology, Chongqing Medical University Affiliated Children’s Hospital, Chongqing, China
Alex Wing Kwan Leung: Department of Pediatrics, Hong Kong Children’s Hospital, The Chinese University of Hong Kong, Hong Kong, Hong Kong SAR, China
Yiying He: Department of Hematology/Oncology, Guangzhou Women and Children’s Medical Center, Guangzhou, China
Yong Zhuang: Department of Pediatrics, Qilu Hospital of Shandong University, Jinan, China
Jinhua Chu: Department of Pediatrics, Anhui Medical University Second Affiliated Hospital, Anhui, China
Xiaowen Zhai: Department of Hematology/Oncology, Children’s Hospital of Fudan University, Shanghai, China
Benquan Qi: 0Department of Pediatrics, State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, China
Aiguo Liu: 1Department of Pediatrics, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
Liangchun Yang: 2Department of Pediatrics, Xiangya Hospital Central South University, Changsha, China
Jiashi Zhu: 3Department of Hematology/Oncology, Children’s Hospital Affiliated to Shanghai Jiao Tong University, Shanghai, China
Zheng Li: 4Department of Hematology/Oncology, Jiangxi Provincial Children’s Hospital, Nanchang, China
Xin Tian: 5Department of Hematology/Oncology, KunMing Children’s Hospital, Kunming, China
Yao Xue: 6Department of Hematology/Oncology, Children’s Hospital of Nanjing Medical University, Nanjing, China
Li Hao: 7Department of Hematology/Oncology, Xi’an Northwest Women’s and Children’s Hospital, Xi’an, China
Xuedong Wu: 8Department of Pediatrics, Nanfang Hospital, Southern Medical University, Guangzhou, China
Fen Zhou: 9Department of Pediatrics, Xiehe Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
Lingzhen Wang: 0Department of Pediatrics, The Affiliated Hospital of Qingdao Medical University, Qingdao, China
Jingyan Tang: Department of Hematology/Oncology, Shanghai Children’s Medical Center, School of Medicine, Shanghai Jiao Tong University, National Health Committee Key Laboratory of Pediatric Hematology and Oncology, Shanghai, China
Shuhong Shen: Department of Hematology/Oncology, Shanghai Children’s Medical Center, School of Medicine, Shanghai Jiao Tong University, National Health Committee Key Laboratory of Pediatric Hematology and Oncology, Shanghai, China
Shaoyan Hu: Department of Hematology, Jiangsu Children Hematology and Oncology Center Children’s Hospital of Soochow University, Suzhou, China

DOI: https://doi.org/10.3389/fcimb.2022.981220
Journal volume & issue: Vol. 12

Abstract

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Background and methodsThe study evaluated prognostic factors associated with varicella-zoster virus (VZV) infection and mortality in children with acute lymphoblastic leukemia (ALL) using data from the multicenter Chinese Children’s Cancer Group ALL-2015 trial.ResultsIn total, 7,640 patients were recruited, and 138 cases of VZV infection were identified. The incidence of VZV infection was higher in patients aged ≥ 10 years (22.5%) and in patients with the E2A/PBX1 fusion gene (11.6%) compared to those aged < 10 years (13.25%, P = 0.003) or with other fusion genes (4.9%, P = 0.001). Of the 10 deaths in children with ALL and VZV infection, 4 resulted from VZV complications. The differences between groups in the 5-year overall survival, event-free survival, cumulative recurrence, and death in remission were not statistically significant. The proportion of complex infection was higher in children with a history of exposure to someone with VZV infection (17.9% vs. 3.6%, P = 0.022).ConclusionVZV exposure was associated with an increased incidence of complex VZV infection and contributed to VZV-associated death in children with ALL.

Published in Frontiers in Cellular and Infection Microbiology

ISSN: 2235-2988 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Science: Microbiology
Website: http://www.frontiersin.org/Cellular-and-Infection-Microbiology

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