Anticancer pH-Responsive Supramolecular Vesicles Fabricated Using Water-Soluble Pillar[5]arene and Curcumin Derivative

Wang Zhang; Jin Yang; Xusen Li; Tianyu Chen; Sumin Park; Minjun Bae; Dayun Jung; Liwei Lin; Sun Ha Paek; Yuanzhe Piao

Materials & Design (Oct 2022)

Anticancer pH-Responsive Supramolecular Vesicles Fabricated Using Water-Soluble Pillar[5]arene and Curcumin Derivative

Wang Zhang,
Jin Yang,
Xusen Li,
Tianyu Chen,
Sumin Park,
Minjun Bae,
Dayun Jung,
Liwei Lin,
Sun Ha Paek,
Yuanzhe Piao

Affiliations

Wang Zhang: School of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou, Jiangsu, 225009, P.R. China; Department of Applied Bioengineering, Graduate School of Convergence Science and Technology, Seoul National University, Suwon-si, Gyeonggi-do, 16229, Republic of Korea; Corresponding authors.
Jin Yang: School of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou, Jiangsu, 225009, P.R. China
Xusen Li: School of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou, Jiangsu, 225009, P.R. China
Tianyu Chen: Department of Applied Bioengineering, Graduate School of Convergence Science and Technology, Seoul National University, Suwon-si, Gyeonggi-do, 16229, Republic of Korea
Sumin Park: Department of Applied Bioengineering, Graduate School of Convergence Science and Technology, Seoul National University, Suwon-si, Gyeonggi-do, 16229, Republic of Korea
Minjun Bae: Department of Applied Bioengineering, Graduate School of Convergence Science and Technology, Seoul National University, Suwon-si, Gyeonggi-do, 16229, Republic of Korea
Dayun Jung: Department of Applied Bioengineering, Graduate School of Convergence Science and Technology, Seoul National University, Suwon-si, Gyeonggi-do, 16229, Republic of Korea
Liwei Lin: Department of Applied Bioengineering, Graduate School of Convergence Science and Technology, Seoul National University, Suwon-si, Gyeonggi-do, 16229, Republic of Korea; Corresponding authors.
Sun Ha Paek: Neurosurgery, Movement Disorder Center, Seoul National University College of Medicine, Advanced Institute of Convergence Technology (AICT), Seoul National University, Seoul 03080, Republic of Korea
Yuanzhe Piao: Department of Applied Bioengineering, Graduate School of Convergence Science and Technology, Seoul National University, Suwon-si, Gyeonggi-do, 16229, Republic of Korea; Advanced Institutes of Convergence Technology, Suwon-si,Gyeonggi-do, 16229, Republic of Korea; Corresponding authors.

Journal volume & issue: Vol. 222
p. 111084

Abstract

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A pH-responsive curcuminoid delivery system based on supramolecular vesicles was fabricated via a novel host–guest inclusion complex between water-soluble pillar[5]arene (WP5) and hydrophobic bisdemethoxycurcumin (BDMC). This WP5 and BDMC (WP5 ⊃ BDMC) inclusion complex was studied using 1H NMR, UV–vis, and fluorescence spectroscopy. This resulting inclusion complex could self-assemble into well-defined supramolecular vesicles by host–guest interactions and presented a significant pH-responsive behavior, which was investigated using dynamic laser scattering, transmission electron microscopy, and UV–vis spectroscopy. The suitable preservation time for WP5 ⊃ BDMC and the construction ratio between host/guest molecules were both of great significance for the aggregated morphology of supramolecular vesicles. Furthermore, the BDMC complexes showed good anticancer ability in vitro, as they could inhibit HepG2 cell proliferation and migration. Therefore, the curcuminoid vesicles could provide a promising platform for drug delivery or food packaging utilization.

Published in Materials & Design

ISSN: 0264-1275 (Print); 1873-4197 (Online)
Publisher: Elsevier
Country of publisher: United Kingdom
LCC subjects: Technology: Electrical engineering. Electronics. Nuclear engineering: Materials of engineering and construction. Mechanics of materials
Website: https://www.journals.elsevier.com/materials-and-design

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