Comparative Evaluation of the Dynamics of Parameters of Cell-Mediated Immunity under the Influence of Different Therapies for Chronic Acquired Toxoplasmosis

Abstract

The article presents a comparative evaluation of the dynamics of parameters of cell-mediated immunity in patients under the influence of different therapies for chronic acquired toxoplasmosis (CAT). Efficiency of complex treatment using antiprotozoal combined drug pyrimethamine + sulfadoxine has been studied in 1 and 5–6 months after starting treatment. After 1 month of initiation of treatment with pyrimethamine + sulfadoxine, a significant increase of CD4+ (p 0.05) and immunoglobulin therapy (t = 1.75; p > 0.05) caused only a trend toward normalization of parameters. After 6 months of starting treatment, a pronounced dynamics was observed in patients received combination therapy (t = 5.5; p < 0.001), average — at immunoglobulin therapy (t = 3.68; p < 0.01) and a small one — in the group of patients treated with pyrimethamine + sulfadoxine (t = 2.91; p < 0.01). Combination therapy had a highest immunological effect when treating patients in the acute stage of CAT. Treatment with T.gondii-specific immunoglobulin took an intermediate position, and therapy using pyrimethamine + sulfadoxine revealed the lowest efficiency.

Keywords

• patients with chronic acquired toxoplasmosis
• diagnosis
• treatment
• parameters of cell-mediated immunity