Nature Communications (May 2022)
A FoxA2+ long-term stem cell population is necessary for growth plate cartilage regeneration after injury
- Shanmugam Muruganandan,
- Rachel Pierce,
- Dian Astari Teguh,
- Rocio Fuente Perez,
- Nicole Bell,
- Brandon Nguyen,
- Katherine Hohl,
- Brian D. Snyder,
- Mark W. Grinstaff,
- Hannah Alberico,
- Dori Woods,
- Yiwei Kong,
- Corneliu Sima,
- Sanket Bhagat,
- Kailing Ho,
- Vicki Rosen,
- Laura Gamer,
- Andreia M. Ionescu
Affiliations
- Shanmugam Muruganandan
- Department of Biology, 134 Mugar Life Sciences Building, Northeastern University
- Rachel Pierce
- Department of Biology, 134 Mugar Life Sciences Building, Northeastern University
- Dian Astari Teguh
- Centre for Advanced Orthopedic Studies, Beth Israel Deaconess Medical Center
- Rocio Fuente Perez
- Division of Pediatrics, University of Oviedo
- Nicole Bell
- New York University College of Dentistry
- Brandon Nguyen
- Moderna Therapeutics
- Katherine Hohl
- Centre for Advanced Orthopedic Studies, Beth Israel Deaconess Medical Center
- Brian D. Snyder
- Department of Orthopedic Surgery, Boston Children’s Hospital
- Mark W. Grinstaff
- Departments of Biomedical Engineering, Chemistry, and Medicine, Boston University
- Hannah Alberico
- Department of Biology, 134 Mugar Life Sciences Building, Northeastern University
- Dori Woods
- Department of Biology, 134 Mugar Life Sciences Building, Northeastern University
- Yiwei Kong
- Department of Biology, 134 Mugar Life Sciences Building, Northeastern University
- Corneliu Sima
- Department of Oral Medicine, Infection, and Immunity, Harvard School of Dental Medicine
- Sanket Bhagat
- Ultragenyx Pharmaceutical
- Kailing Ho
- Department of Developmental Biology, Harvard School of Dental Medicine
- Vicki Rosen
- Department of Developmental Biology, Harvard School of Dental Medicine
- Laura Gamer
- Department of Developmental Biology, Harvard School of Dental Medicine
- Andreia M. Ionescu
- Department of Biology, 134 Mugar Life Sciences Building, Northeastern University
- DOI
- https://doi.org/10.1038/s41467-022-30247-1
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 15
Abstract
The growth plate cartilage supports long bone growth. Here the authors identify FoxA2+ long term stem cells in the growth plate that are stratified with short term PTHrP+ cells, participate in production of hyaline cartilage, expand in response to trauma, and whose ablation impairs cartilage regeneration.
