A novel, swift, and effective green synthesis of morpholino-pyridine analogues in microwave irradiation conditions

Abstract

We report a facile, efficient, and environmentally benign approach for preparing morpholino-linked 1,4-dihydropyridine derivatives. The four-component fusion of morpholin-4-amine, diethyl acetylene dicarboxylate, malononitrile, and chosen substituted benzaldehydes occurred under microwave irradiation under mild conditions in the presence of potassium carbonate as a catalyst. This protocol offers remarkable benefits such as excellent yields (92–98 %), easy handling, simple workup, economy, cleaner reaction profile, green conditions, shorter reaction time (≤10 min), and avoiding column chromatography for purification.

Keywords

• Green organic synthesis
• Microwave irradiation
• MCRs
• One-pot protocol
• 1,4-Dihydropyridine-2,3-dicarboxylate
• Potassium carbonate