A murine neonatal model of necrotizing enterocolitis caused by anemia and red blood cell transfusions

Krishnan MohanKumar; Kopperuncholan Namachivayam; Tanjing Song; Byeong Jake Cha; Andrea Slate; Jeanne E. Hendrickson; Hua Pan; Samuel A. Wickline; Joo-Yeun Oh; Rakesh P. Patel; Ling He; Benjamin A. Torres; Akhil Maheshwari

doi:10.1038/s41467-019-11199-5

Nature Communications (Aug 2019)

A murine neonatal model of necrotizing enterocolitis caused by anemia and red blood cell transfusions

Krishnan MohanKumar,
Kopperuncholan Namachivayam,
Tanjing Song,
Byeong Jake Cha,
Andrea Slate,
Jeanne E. Hendrickson,
Hua Pan,
Samuel A. Wickline,
Joo-Yeun Oh,
Rakesh P. Patel,
Ling He,
Benjamin A. Torres,
Akhil Maheshwari

Affiliations

Krishnan MohanKumar: Department of Pediatrics, Morsani College of Medicine, University of South Florida
Kopperuncholan Namachivayam: Department of Pediatrics, Morsani College of Medicine, University of South Florida
Tanjing Song: Department of Pediatrics, Morsani College of Medicine, University of South Florida
Byeong Jake Cha: Department of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida
Andrea Slate: Department of Comparative Medicine, University of South Florida
Jeanne E. Hendrickson: Department of Laboratory Medicine, Yale School of Medicine
Hua Pan: Department of Cardiology, Morsani College of Medicine, University of South Florida
Samuel A. Wickline: Department of Cardiology, Morsani College of Medicine, University of South Florida
Joo-Yeun Oh: Center for Free Radical Biology, University of Alabama at Birmingham
Rakesh P. Patel: Center for Free Radical Biology, University of Alabama at Birmingham
Ling He: Department of Pediatrics, Johns Hopkins University
Benjamin A. Torres: Department of Pediatrics, Morsani College of Medicine, University of South Florida
Akhil Maheshwari: Department of Pediatrics, Morsani College of Medicine, University of South Florida

DOI: https://doi.org/10.1038/s41467-019-11199-5
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 17

Abstract

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The development of neonatal necrotising enterocolitis has been temporally associated with red blood cell transfusions in retrospective human studies. Here, the authors develop a neonatal mouse model of necrotising enterocolitis in anaemic mice receiving red blood cell transfusion that recapitulates features of the human condition.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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