Communications Biology (Mar 2023)
Antimicrobial protein REG3A regulates glucose homeostasis and insulin resistance in obese diabetic mice
- Patrick Gonzalez,
- Alexandre Dos Santos,
- Marion Darnaud,
- Nicolas Moniaux,
- Delphine Rapoud,
- Claire Lacoste,
- Tung-Son Nguyen,
- Valentine S. Moullé,
- Alice Deshayes,
- Gilles Amouyal,
- Paul Amouyal,
- Christian Bréchot,
- Céline Cruciani-Guglielmacci,
- Fabrizio Andréelli,
- Christophe Magnan,
- Jamila Faivre
Affiliations
- Patrick Gonzalez
- INSERM, U1193, Paul-Brousse University Hospital, Hepatobiliary Centre
- Alexandre Dos Santos
- INSERM, U1193, Paul-Brousse University Hospital, Hepatobiliary Centre
- Marion Darnaud
- INSERM, U1193, Paul-Brousse University Hospital, Hepatobiliary Centre
- Nicolas Moniaux
- INSERM, U1193, Paul-Brousse University Hospital, Hepatobiliary Centre
- Delphine Rapoud
- INSERM, U1193, Paul-Brousse University Hospital, Hepatobiliary Centre
- Claire Lacoste
- INSERM, U1193, Paul-Brousse University Hospital, Hepatobiliary Centre
- Tung-Son Nguyen
- INSERM, U1193, Paul-Brousse University Hospital, Hepatobiliary Centre
- Valentine S. Moullé
- Université of Paris, Unité de Biologie Fonctionnelle et Adaptative
- Alice Deshayes
- INSERM, U1193, Paul-Brousse University Hospital, Hepatobiliary Centre
- Gilles Amouyal
- Alfact Innovation
- Paul Amouyal
- Alfact Innovation
- Christian Bréchot
- USF Health, University of South Florida
- Céline Cruciani-Guglielmacci
- Université of Paris, Unité de Biologie Fonctionnelle et Adaptative
- Fabrizio Andréelli
- Sorbonne Université, INSERM, NutriOmics team, Institute of Cardiometabolism and Nutrition (ICAN), Assistance Publique-Hôpitaux de Paris, Pitié-Salpêtrière Hospital
- Christophe Magnan
- Université of Paris, Unité de Biologie Fonctionnelle et Adaptative
- Jamila Faivre
- INSERM, U1193, Paul-Brousse University Hospital, Hepatobiliary Centre
- DOI
- https://doi.org/10.1038/s42003-023-04616-5
- Journal volume & issue
-
Vol. 6,
no. 1
pp. 1 – 17
Abstract
Antimicrobial protein REG3A improved insulin sensitivity by combating oxidative stress and activating AMPK in skeletal muscle in HFD-induced obese mice overexpressing human REG3A in the liver.
