Investigating the effectiveness of aerobic exercise along with nano curcumin supplementation in behavioral-motor disorders in rats with a brain tumor

Abstract

Introduction: Any defect and abnormal growth in brain cells in an uncontrolled manner leads to the creation of a tumor and disruption of its normal functional capabilities. Therefore, the present study aimed to investigate the effectiveness of aerobic exercise along with nano curcumin supplementation in behavioral-motor disorders in rats with brain tumors. Material & Methods: A total of 35 male Wistar rats were randomly assigned to seven groups of 5: basic healthy control, four weeks healthy, basic cancer control, four weeks cancer, cancer-nano curcumin, cancer-exercise, and cancer-exercise-nano curcumin groups. One week after the injection of cancer cells in the frontal cortex, the animals entered the main training program on the treadmill (4 weeks, with a speed of 18 meters per minute, 25-40 minutes, three days a week). The data were analyzed in SPSS software (version 26) using the statistical test of one-way analysis of variance. Findings: The results pointed out that behavioral-motor disorders in the training group, nano curcumin, and the training group-nano curcumin were significantly less than in the 4-week cancer control group (P=0.001). Discussion & Conclusion: It seems that aerobic exercise, along with a suitable dose of nano curcumin as a therapeutic supplement along with other methods, can reduce behavioral-motor disorders in cancerous rats, possibly by increasing brain blood flow, neurogenesis, and nerve synapses.

Keywords

• aerobic exercise
• behavioral-motor disorders
• brain tumor
• nano curcumin supplement