Palladium and Organocatalysis: An Excellent Recipe for Asymmetric Synthesis

Abstract

The dual activation of simple substrates by the combination of organocatalysis and palladium catalysis has been successfully applied in a variety of different asymmetric transformations. Thus, the asymmetric a-allylation of carbonyl compounds, a-fluorination of acyl derivatives, decarboxylative protonation of β-dicarbonyl compounds, cyclization reactions of alkynyl carbonyl compounds and β-functionalization of aldehydes have been efficiently achieved employing this double-catalytic methodology.

Keywords

• palladium
• organocatalysis
• asymmetric synthesis
• dual activation
• tandem reaction
• allylation
• fluorination
• decarboxylative protonation