Nature Communications (Jun 2022)
Omicron-specific mRNA vaccination alone and as a heterologous booster against SARS-CoV-2
- Zhenhao Fang,
- Lei Peng,
- Renata Filler,
- Kazushi Suzuki,
- Andrew McNamara,
- Qianqian Lin,
- Paul A. Renauer,
- Luojia Yang,
- Bridget Menasche,
- Angie Sanchez,
- Ping Ren,
- Qiancheng Xiong,
- Madison Strine,
- Paul Clark,
- Chenxiang Lin,
- Albert I. Ko,
- Nathan D. Grubaugh,
- Craig B. Wilen,
- Sidi Chen
Affiliations
- Zhenhao Fang
- Department of Genetics, Yale University School of Medicine
- Lei Peng
- Department of Genetics, Yale University School of Medicine
- Renata Filler
- Department of Laboratory Medicine, Yale University
- Kazushi Suzuki
- Department of Genetics, Yale University School of Medicine
- Andrew McNamara
- Department of Laboratory Medicine, Yale University
- Qianqian Lin
- Department of Genetics, Yale University School of Medicine
- Paul A. Renauer
- Department of Genetics, Yale University School of Medicine
- Luojia Yang
- Department of Genetics, Yale University School of Medicine
- Bridget Menasche
- Department of Laboratory Medicine, Yale University
- Angie Sanchez
- Department of Genetics, Yale University School of Medicine
- Ping Ren
- Department of Genetics, Yale University School of Medicine
- Qiancheng Xiong
- Department of Cell Biology, Yale University
- Madison Strine
- Department of Laboratory Medicine, Yale University
- Paul Clark
- Department of Genetics, Yale University School of Medicine
- Chenxiang Lin
- Department of Cell Biology, Yale University
- Albert I. Ko
- Department of Epidemiology of Microbial Diseases, Yale School of Public Health
- Nathan D. Grubaugh
- Department of Epidemiology of Microbial Diseases, Yale School of Public Health
- Craig B. Wilen
- Department of Laboratory Medicine, Yale University
- Sidi Chen
- Department of Genetics, Yale University School of Medicine
- DOI
- https://doi.org/10.1038/s41467-022-30878-4
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 12
Abstract
Here the authors show that Omicron neutralizing antibody titers decline over time in mice immunized with a wild-type (WT) lipid nanoparticle (LNP)-mRNA vaccine and are robustly increased by WT or Omicron LNP-mRNA and that Omicron boosters elicit higher BA.1-neutralizing titer than WT boosters.
