The Application of Lipoic Acid in Experimentally Induced Tympanosclerosis in Rats

Abstract

AbstractBackground/Aims:Tympanosclerosis is an abnormal tissue reaction resulting in sclerotic and hyalinization changes in the tympanic membrane and middle ear. We hypothesized that alpha lipoic acid, an antioxidant, may represent a simple and effective form of treatment in inflammattion-related tympanosclerosis. The purpose of the study was to investigate the effects of alpha lipoic acid on experimentally induced inflammattion-related tympanosclerosis in rats.Methods:Twenty albino Wistar rats were randomly divided into two equal groups. The first (study) group was administered 50 mg/kg alpha lipoic acid by the intraperitoneal route once daily for 7 days. The second group was administered the same saline solution intraperitoneally once daily for 7 days. Inflammation, fibrosis and lamina propria thickness were assessed at the subsequent histopathological examination.Results:In the study group, significantly less middle ear inflammation and fibrosis developed and the tympanic membrane lamina propria was thinner compared to the control group. Conclusions: Alpha lipoic acid was found capable of preventing experimentally induced inflammattion-related tympanosclerosis with its antioxidant characteristics.

Keywords

• alpha lipoic acid
• inflammation
• fibrosis
• fibrosis
• alfa-lipoik asit
• inflamasyon
• fibroz