Nature Communications (Nov 2018)
Germline variation at 8q24 and prostate cancer risk in men of European ancestry
- Marco Matejcic,
- Edward J. Saunders,
- Tokhir Dadaev,
- Mark N. Brook,
- Kan Wang,
- Xin Sheng,
- Ali Amin Al Olama,
- Fredrick R. Schumacher,
- Sue A. Ingles,
- Koveela Govindasami,
- Sara Benlloch,
- Sonja I. Berndt,
- Demetrius Albanes,
- Stella Koutros,
- Kenneth Muir,
- Victoria L. Stevens,
- Susan M. Gapstur,
- Catherine M. Tangen,
- Jyotsna Batra,
- Judith Clements,
- Henrik Gronberg,
- Nora Pashayan,
- Johanna Schleutker,
- Alicja Wolk,
- Catharine West,
- Lorelei Mucci,
- Peter Kraft,
- Géraldine Cancel-Tassin,
- Karina D. Sorensen,
- Lovise Maehle,
- Eli M. Grindedal,
- Sara S. Strom,
- David E. Neal,
- Freddie C. Hamdy,
- Jenny L. Donovan,
- Ruth C. Travis,
- Robert J. Hamilton,
- Barry Rosenstein,
- Yong-Jie Lu,
- Graham G. Giles,
- Adam S. Kibel,
- Ana Vega,
- Jeanette T. Bensen,
- Manolis Kogevinas,
- Kathryn L. Penney,
- Jong Y. Park,
- Janet L. Stanford,
- Cezary Cybulski,
- Børge G. Nordestgaard,
- Hermann Brenner,
- Christiane Maier,
- Jeri Kim,
- Manuel R. Teixeira,
- Susan L. Neuhausen,
- Kim De Ruyck,
- Azad Razack,
- Lisa F. Newcomb,
- Davor Lessel,
- Radka Kaneva,
- Nawaid Usmani,
- Frank Claessens,
- Paul A. Townsend,
- Manuela Gago-Dominguez,
- Monique J. Roobol,
- Florence Menegaux,
- Kay-Tee Khaw,
- Lisa A. Cannon-Albright,
- Hardev Pandha,
- Stephen N. Thibodeau,
- Daniel J. Schaid,
- The PRACTICAL (Prostate Cancer Association Group to Investigate Cancer-Associated Alterations in the Genome) Consortium,
- Fredrik Wiklund,
- Stephen J. Chanock,
- Douglas F. Easton,
- Rosalind A. Eeles,
- Zsofia Kote-Jarai,
- David V. Conti,
- Christopher A. Haiman
Affiliations
- Marco Matejcic
- Department of Preventive Medicine, Keck School of Medicine, University of Southern California/Norris Comprehensive Cancer Center
- Edward J. Saunders
- The Institute of Cancer Research
- Tokhir Dadaev
- The Institute of Cancer Research
- Mark N. Brook
- The Institute of Cancer Research
- Kan Wang
- Department of Preventive Medicine, Keck School of Medicine, University of Southern California/Norris Comprehensive Cancer Center
- Xin Sheng
- Department of Preventive Medicine, Keck School of Medicine, University of Southern California/Norris Comprehensive Cancer Center
- Ali Amin Al Olama
- Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, Strangeways Research Laboratory, University of Cambridge
- Fredrick R. Schumacher
- Department of Population and Quantitative Health Sciences, Case Western Reserve University
- Sue A. Ingles
- Department of Preventive Medicine, Keck School of Medicine, University of Southern California/Norris Comprehensive Cancer Center
- Koveela Govindasami
- The Institute of Cancer Research
- Sara Benlloch
- The Institute of Cancer Research
- Sonja I. Berndt
- Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH
- Demetrius Albanes
- Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH
- Stella Koutros
- Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH
- Kenneth Muir
- Institute of Population Health, University of Manchester
- Victoria L. Stevens
- Epidemiology Research Program, American Cancer Society
- Susan M. Gapstur
- Epidemiology Research Program, American Cancer Society
- Catherine M. Tangen
- SWOG Statistical Center, Fred Hutchinson Cancer Research Center
- Jyotsna Batra
- Australian Prostate Cancer Research Centre-Qld, Institute of Health and Biomedical Innovation and School of Biomedical Science, Queensland University of Technology
- Judith Clements
- Australian Prostate Cancer Research Centre-Qld, Institute of Health and Biomedical Innovation and School of Biomedical Science, Queensland University of Technology
- Henrik Gronberg
- Department of Medical Epidemiology and Biostatistics, Karolinska Institute
- Nora Pashayan
- Centre for Cancer Genetic Epidemiology, Department of Oncology, Strangeways Research Laboratory, University of Cambridge
- Johanna Schleutker
- Department of Medical Biochemistry and Genetics, Institute of Biomedicine, University of Turku
- Alicja Wolk
- Division of Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet
- Catharine West
- Division of Cancer Sciences, Manchester Academic Health Science Centre, Radiotherapy Related Research, Manchester NIHR Biomedical Research Centre, The Christie Hospital NHS Foundation Trust, University of Manchester
- Lorelei Mucci
- Department of Epidemiology, Harvard School of Public Health
- Peter Kraft
- Program in Genetic Epidemiology and Statistical Genetics, Department of Epidemiology, Harvard T.H. Chan School of Public Health
- Géraldine Cancel-Tassin
- GRC N°5 ONCOTYPE-URO, UPMC Univ Paris 06, Tenon Hospital
- Karina D. Sorensen
- Department of Molecular Medicine, Aarhus University Hospital
- Lovise Maehle
- Department of Medical Genetics, Oslo University Hospital
- Eli M. Grindedal
- Department of Medical Genetics, Oslo University Hospital
- Sara S. Strom
- Department of Epidemiology, The University of Texas MD Anderson Cancer Center
- David E. Neal
- Department of Oncology, Addenbrooke’s Hospital, University of Cambridge
- Freddie C. Hamdy
- Nuffield Department of Surgical Sciences, University of Oxford
- Jenny L. Donovan
- School of Social and Community Medicine, University of Bristol, Canynge Hall
- Ruth C. Travis
- Cancer Epidemiology, Nuffield Department of Population Health, University of Oxford
- Robert J. Hamilton
- Department of Surgical Oncology, Princess Margaret Cancer Centre
- Barry Rosenstein
- Department of Radiation Oncology, Icahn School of Medicine at Mount Sinai
- Yong-Jie Lu
- Centre for Molecular Oncology, John Vane Science Centre, Barts Cancer Institute, Queen Mary University of London
- Graham G. Giles
- Cancer Epidemiology & Intelligence Division, Cancer Council Victoria
- Adam S. Kibel
- Division of Urologic Surgery, Brigham and Womens Hospital
- Ana Vega
- Fundación Pública Galega de Medicina Xenómica-SERGAS, Grupo de Medicina Xenómica, CIBERER, IDIS
- Jeanette T. Bensen
- Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina
- Manolis Kogevinas
- Centre for Research in Environmental Epidemiology (CREAL), Barcelona Institute for Global Health (ISGlobal)
- Kathryn L. Penney
- Channing Division of Network Medicine, Department of Medicine, Brigham and Women’s Hospital/Harvard Medical School
- Jong Y. Park
- Department of Cancer Epidemiology, Moffitt Cancer Center
- Janet L. Stanford
- Division of Public Health Sciences, Fred Hutchinson Cancer Research Center
- Cezary Cybulski
- International Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University
- Børge G. Nordestgaard
- Faculty of Health and Medical Sciences, University of Copenhagen
- Hermann Brenner
- Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ)
- Christiane Maier
- Institute for Human Genetics, University Hospital Ulm
- Jeri Kim
- Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center
- Manuel R. Teixeira
- Department of Genetics, Portuguese Oncology Institute of Porto
- Susan L. Neuhausen
- Department of Population Sciences, Beckman Research Institute of the City of Hope
- Kim De Ruyck
- Ghent University, Faculty of Medicine and Health Sciences, Basic Medical Sciences
- Azad Razack
- Department of Surgery, Faculty of Medicine, University of Malaya
- Lisa F. Newcomb
- Division of Public Health Sciences, Fred Hutchinson Cancer Research Center
- Davor Lessel
- Institute of Human Genetics, University Medical Center Hamburg-Eppendorf
- Radka Kaneva
- Molecular Medicine Center, Department of Medical Chemistry and Biochemistry, Medical University of Sofia
- Nawaid Usmani
- Department of Oncology, Cross Cancer Institute, University of Alberta
- Frank Claessens
- Molecular Endocrinology Laboratory, Department of Cellular and Molecular Medicine, KU Leuven
- Paul A. Townsend
- Manchester Cancer Research Centre, Faculty of Biology Medicine and Health, Manchester Academic Health Science Centre, NIHR Manchester Biomedical Research Centre, Health Innovation Manchester, University of Manchester
- Manuela Gago-Dominguez
- Genomic Medicine Group, Galician Foundation of Genomic Medicine, Instituto de Investigacion Sanitaria de Santiago de Compostela (IDIS), Complejo Hospitalario Universitario de Santiago, Servicio Galego de Saúde, SERGAS
- Monique J. Roobol
- Department of Urology, Erasmus University Medical Center
- Florence Menegaux
- Cancer and Environment Group, Center for Research in Epidemiology and Population Health (CESP), INSERM, University Paris-Sud, University Paris-Saclay
- Kay-Tee Khaw
- Clinical Gerontology Unit, University of Cambridge
- Lisa A. Cannon-Albright
- Division of Genetic Epidemiology, Department of Medicine, University of Utah School of Medicine
- Hardev Pandha
- The University of Surrey, Guildford
- Stephen N. Thibodeau
- Department of Laboratory Medicine and Pathology, Mayo Clinic
- Daniel J. Schaid
- Division of Biomedical Statistics and Informatics, Mayo Clinic
- The PRACTICAL (Prostate Cancer Association Group to Investigate Cancer-Associated Alterations in the Genome) Consortium
- Fredrik Wiklund
- Department of Medical Epidemiology and Biostatistics, Karolinska Institute
- Stephen J. Chanock
- Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH
- Douglas F. Easton
- Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, Strangeways Research Laboratory, University of Cambridge
- Rosalind A. Eeles
- The Institute of Cancer Research
- Zsofia Kote-Jarai
- The Institute of Cancer Research
- David V. Conti
- Department of Preventive Medicine, Keck School of Medicine, University of Southern California/Norris Comprehensive Cancer Center
- Christopher A. Haiman
- Department of Preventive Medicine, Keck School of Medicine, University of Southern California/Norris Comprehensive Cancer Center
- DOI
- https://doi.org/10.1038/s41467-018-06863-1
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 11
Abstract
Chromosome 8q24 is known to be a major susceptibility region for prostate cancer risk. Here the authors analyze genetic data across the 8q24 region from 71,535 prostate cancer patients identifying 12 risk loci, three previously unreported, highlighting the contribution of germline variation at this locus.
