Comparison of Microperimetry and Static Perimetry for Evaluating Macular Function and Progression in Retinitis Pigmentosa

Masatoshi Fukushima, MD; Yan Tao, MD; Sakurako Shimokawa, MD; Huanyu Zhao, MD; Shotaro Shimokawa, MD, PhD; Jun Funatsu, MD, PhD; Takahiro Hisai, MD; Ayako Okita, MD, PhD; Kohta Fujiwara, MD, PhD; Toshio Hisatomi, MD, PhD; Atsunobu Takeda, MD, PhD; Yasuhiro Ikeda, MD, PhD; Koh-Hei Sonoda, MD, PhD; Yusuke Murakami, MD, PhD

Ophthalmology Science (Nov 2024)

Comparison of Microperimetry and Static Perimetry for Evaluating Macular Function and Progression in Retinitis Pigmentosa

Masatoshi Fukushima, MD,
Yan Tao, MD,
Sakurako Shimokawa, MD,
Huanyu Zhao, MD,
Shotaro Shimokawa, MD, PhD,
Jun Funatsu, MD, PhD,
Takahiro Hisai, MD,
Ayako Okita, MD, PhD,
Kohta Fujiwara, MD, PhD,
Toshio Hisatomi, MD, PhD,
Atsunobu Takeda, MD, PhD,
Yasuhiro Ikeda, MD, PhD,
Koh-Hei Sonoda, MD, PhD,
Yusuke Murakami, MD, PhD

Affiliations

Masatoshi Fukushima, MD: Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
Yan Tao, MD: Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
Sakurako Shimokawa, MD: Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
Huanyu Zhao, MD: Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
Shotaro Shimokawa, MD, PhD: Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
Jun Funatsu, MD, PhD: Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
Takahiro Hisai, MD: Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
Ayako Okita, MD, PhD: Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
Kohta Fujiwara, MD, PhD: Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
Toshio Hisatomi, MD, PhD: Department of Ophthalmology, Fukuoka University Chikushi Hospital, Fukuoka, Japan
Atsunobu Takeda, MD, PhD: Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan; Department of Ophthalmology, Graduate School of Medicine, Oita University, Oita, Japan
Yasuhiro Ikeda, MD, PhD: Department of Ophthalmology, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan
Koh-Hei Sonoda, MD, PhD: Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
Yusuke Murakami, MD, PhD: Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan; Correspondence: Yusuke Murakami, MD, PhD, Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, 812-8582, Japan.

Journal volume & issue: Vol. 4, no. 6
p. 100582

Abstract

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Purpose: To compare the usefulness of microperimetry and static automated perimetry in patients with retinitis pigmentosa (RP), using macular anatomical metrics as a reference. Design: Prospective observational study. Participants: Forty-eight eyes of 48 patients with RP in Kyushu University Hospital who underwent microperimetry-3 (MP-3) and Humphrey Field Analyzer (HFA) 10-2 testing ≥3 times during ≥2 years were included. Methods: Macular anatomy (ellipsoid zone [EZ] length) was assessed by OCT, and macular function was assessed by MP-3 (mean retinal sensitivity at radii 2°, 4°, and 8°) and HFA10-2 program (mean retinal sensitivity at radii 2°, 4°, and 8°). Correlations between functional and anatomical parameters were analyzed cross sectionally at baseline and longitudinally by comparing the rate of progression. Main Outcome Measures: Correlation coefficients between anatomical and functional metrics. Results: The mean age at baseline was 50.1 ± 12.3 years, and the mean follow-up period was 2.8 ± 0.7 years. At baseline, EZ length was significantly correlated with MP-3 mean retinal sensitivity at radii 2°, 4°, and 8° (Spearman’s ρ = 0.65, 0.84, 0.89; all P < 0.005) and HFA10-2 mean retinal sensitivity at radii 2°, 4°, and 8° (Spearman’s ρ = 0.61, 0.73, 0.78; all P < 0.005). Longitudinal analysis showed that the slope of EZ length (−88.92 μm/year) was significantly correlated with the slope of MP-3 retinal sensitivity at 8° radius (−0.62 decibels [dB]/year; Spearman’s ρ = 0.31, P=0.03) and the slope of HFA retinal sensitivity at 8° radius (−0.60 dB/year; Spearman’s ρ = 0.43, P < 0.005). Conclusions: Both MP-3 and HFA values were cross sectionally well-correlated with EZ length in patients with patients; however, these associations became weaker in the longitudinal analysis. This highlights the need for researchers to explore additional or more sensitive parameters to better monitor RP progression. Financial Disclosure(s): Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.

Published in Ophthalmology Science

ISSN: 2666-9145 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Medicine: Ophthalmology
Website: https://www.journals.elsevier.com/ophthalmology-science/

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