Medication Adherence and Its Influencing Factors Among Inflammatory Bowel Disease Patients in China

Abstract

Fen Xu,1,* Juping Tang,1,* Zhiping Zhu,2 Yan Chen,3 Wen Hu,4 Sha Lu,5 Yunxian Zhou,6 Ding Lin7 1Department of Nursing, Hangzhou Third Hospital, Hangzhou, People’s Republic of China; 2Department of Vascular Surgery, Hangzhou Third Hospital, Hangzhou, People’s Republic of China; 3Department of Gastroenterology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, People’s Republic of China; 4State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative National Clinical Research Center for Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, People’s Republic of China; 5Department of Obstetrics and Gynecology, Hangzhou Women’s Hospital (Hangzhou Maternity and Child Health Care Hospital), Hangzhou, People’s Republic of China; 6School of Nursing, Zhejiang Chinese Medical University, Hangzhou, People’s Republic of China; 7Department of Cardiovascular Medicine, Hangzhou Third Hospital, Hangzhou, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yunxian Zhou, School of Nursing, Zhejiang Chinese Medical University, 548 Binwen Road, Binjiang District, Hangzhou, Zhejiang, 310053, People’s Republic of China, Tel [phone], Email [email protected] Ding Lin, Department of Cardiovascular Medicine, Hangzhou Third Hospital, No. 38 Xihu Road, Hangzhou, Zhejiang Province, 310009, People’s Republic of China, Tel [phone], Email [email protected]: To investigate the current state of medication adherence among patients with inflammatory bowel disease (IBD) in China and analyze the influencing factors.Patients and Methods: We recruited as many eligible subjects as possible and a total of 105 patients with IBD finished this cross-sectional survey. The General Information Questionnaire and Morisky Medication Adherence Scale were used as measurement instruments. The factors influencing the Morisky score were studied by multiple linear regression analysis.Results: The average Morisky score was 6.11 ± 1.93. Univariate analysis showed that there were statistically significant differences in Morisky scores among patients with different ages, education levels, disease types, medication administration methods, medication frequencies, disease understanding and knowledge learning frequencies (P < 0.05). Multiple stepwise linear regression analyses showed that medication frequency, medication administration method and disease understanding were important factors influencing the Morisky score (P < 0.001).Conclusion: Our data confirmed that the medication adherence of IBD patients was poor, especially among patients taking oral medication, those taking medications with a high frequency and those with a low understanding of the disease. To reduce symptom recurrence and control the disease, medical staff should pay attention to the individual patient factors, simplify the medication regimens, formulate effective coping strategies for drug management support.Keywords: Crohn’s disease, inflammatory bowel disease, medication adherence, ulcerative colitis

Keywords

• crohn's disease
• inflammatory bowel disease
• medication adherence
• ulcerative colitis