Nature Communications (Nov 2016)

BRCA1-regulated RRM2 expression protects glioblastoma cells from endogenous replication stress and promotes tumorigenicity

  • Rikke D. Rasmussen,
  • Madhavsai K. Gajjar,
  • Lucie Tuckova,
  • Kamilla E. Jensen,
  • Apolinar Maya-Mendoza,
  • Camilla B. Holst,
  • Kjeld Møllgaard,
  • Jane S. Rasmussen,
  • Jannick Brennum,
  • Jiri Bartek,
  • Martin Syrucek,
  • Eva Sedlakova,
  • Klaus K. Andersen,
  • Marie H. Frederiksen,
  • Jiri Bartek,
  • Petra Hamerlik

DOI
https://doi.org/10.1038/ncomms13398
Journal volume & issue
Vol. 7, no. 1
pp. 1 – 14

Abstract

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BRCA1 loss can result in collapse of replication forks into DNA double strand breaks that can contribute to malignant transformation. Here, the authors find that BRCA1 promotes the expression of RRM2 protecting glioblastoma cells from replication stress, DNA damage and apoptosis.