OncoTargets and Therapy (Jul 2020)
Role of αVβ3 in Prostate Cancer: Metastasis Initiator and Important Therapeutic Target
Abstract
Lin Tang,1 Meng Xu,2,3 Long Zhang,4 Lin Qu,5 Xiaoyan Liu6 1College of Mathematics and Computer Science, Chifeng University, Chifeng, The Inner Mongol Autonomous Region 024005, People’s Republic of China; 2Department of Urology, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou, Liaoning 121000, People’s Republic of China; 3R&D Department, Seekgene Technology Co., Ltd, Beijing 100000, People’s Republic of China; 4Department of Hepatobiliary Surgery, Yidu Central Hospital, Weifang, Shandong 262500, People’s Republic of China; 5Department of Orthopaedic Surgery, Anshan Hospital of the First Hospital of China Medical University, Anshan, Liaoning 114000, People’s Republic of China; 6Department of Pathology, The Fifth Medical Center of Chinese PLA General Hospital, Beijing 100000, People’s Republic of ChinaCorrespondence: Meng XuJinzhou Medical University, Songpo Road, Jinzhou, Liaoning 121000, People’s Republic of ChinaEmail [email protected]: In prostate cancer, distant organ metastasis is the leading cause of patient death. Although the mechanism of malignant tumor metastasis is unclear, studies have confirmed that integrin αVβ 3 plays an important role in this process. In prostate cancer, αVβ 3 mediates adhesion, invasion, immune escape and neovascularization through interactions with different ligands. Among these ligands and in addition to proteins that are directly related to tumor invasion, other proteins that contain the RGD structure could also bind to αVβ 3 and cause a number of biological effects. In this article, we summarized the ligand and downstream proteins related to αVβ 3-mediated prostate cancer metastasis as well as some diagnostic and therapeutic measures targeting αVβ 3.Keywords: prostate cancer, metastasis, αVβ 3, signal pathway
