Nature Communications (Sep 2017)

Network heterogeneity regulates steering in actin-based motility

  • Rajaa Boujemaa-Paterski,
  • Cristian Suarez,
  • Tobias Klar,
  • Jie Zhu,
  • Christophe Guérin,
  • Alex Mogilner,
  • Manuel Théry,
  • Laurent Blanchoin

DOI
https://doi.org/10.1038/s41467-017-00455-1
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 13

Abstract

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Protrusive cellular structures contain a heterogeneous density of actin, but whether this influences motility is not known. Using an in vitro system and modelling, here the authors show that local actin monomer depletion and network architecture can tune the rate of network growth to impose steering during motility.