Local membrane charge regulates β2 adrenergic receptor coupling to Gi3

M. J. Strohman; S. Maeda; D. Hilger; M. Masureel; Y. Du; B. K. Kobilka

doi:10.1038/s41467-019-10108-0

Nature Communications (May 2019)

Local membrane charge regulates β2 adrenergic receptor coupling to Gi3

M. J. Strohman,
S. Maeda,
D. Hilger,
M. Masureel,
Y. Du,
B. K. Kobilka

Affiliations

M. J. Strohman: Department of Molecular and Cellular Physiology, Stanford University School of Medicine
S. Maeda: Department of Molecular and Cellular Physiology, Stanford University School of Medicine
D. Hilger: Department of Molecular and Cellular Physiology, Stanford University School of Medicine
M. Masureel: Department of Molecular and Cellular Physiology, Stanford University School of Medicine
Y. Du: Department of Molecular and Cellular Physiology, Stanford University School of Medicine
B. K. Kobilka: Department of Molecular and Cellular Physiology, Stanford University School of Medicine

DOI: https://doi.org/10.1038/s41467-019-10108-0
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 10

Abstract

Read online

In the healthy heart, the β2 adrenergic receptor (β2AR) signals through Gs and Gi proteins but the mechanism underlying G protein selectivity is not fully understood. Here, the authors show that membrane charge and intracellular cations modulate the β2AR−Gi3 interaction.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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