Fetal Hydantoin Syndrome

Abstract

In a prospective study of 19 pregnancies monitored by amniocentesis at the Center for Human Genetics and the Meyer Rehabilitation Institute, University of Nebraska, Omaha, an adverse outcome was predicted for four fetuses on the basis of low epoxide hydrolase activity (30% of standard).

Keywords

• amniocentesis
• phenytoin monotherapy
• enzymatic biomarker