Emerging Infectious Diseases (Sep 2021)
Predictors of Nonseroconversion after SARS-CoV-2 Infection
- Weimin Liu,
- Ronnie M. Russell,
- Frederic Bibollet-Ruche,
- Ashwin N. Skelly,
- Scott Sherrill-Mix,
- Drew A. Freeman,
- Regina Stoltz,
- Emily Lindemuth,
- Fang-Hua Lee,
- Sarah Sterrett,
- Katharine J. Bar,
- Nathaniel Erdmann,
- Sigrid Gouma,
- Scott E. Hensley,
- Thomas Ketas,
- Albert Cupo,
- Victor M. Cruz Portillo,
- John P. Moore,
- Paul D. Bieniasz,
- Theodora Hatziioannou,
- Greer Massey,
- Mary-Beth Minyard,
- Michael S. Saag,
- Randall S. Davis,
- George M. Shaw,
- William J. Britt,
- Sixto M. Leal,
- Paul Goepfert,
- Beatrice H. Hahn
Affiliations
- Weimin Liu
- Ronnie M. Russell
- Frederic Bibollet-Ruche
- Ashwin N. Skelly
- Scott Sherrill-Mix
- Drew A. Freeman
- Regina Stoltz
- Emily Lindemuth
- Fang-Hua Lee
- Sarah Sterrett
- Katharine J. Bar
- Nathaniel Erdmann
- Sigrid Gouma
- Scott E. Hensley
- Thomas Ketas
- Albert Cupo
- Victor M. Cruz Portillo
- John P. Moore
- Paul D. Bieniasz
- Theodora Hatziioannou
- Greer Massey
- Mary-Beth Minyard
- Michael S. Saag
- Randall S. Davis
- George M. Shaw
- William J. Britt
- Sixto M. Leal
- Paul Goepfert
- Beatrice H. Hahn
- DOI
- https://doi.org/10.3201/eid2709.211042
- Journal volume & issue
-
Vol. 27,
no. 9
pp. 2454 – 2458
Abstract
Not all persons recovering from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection develop SARS-CoV-2–specific antibodies. We show that nonseroconversion is associated with younger age and higher reverse transcription PCR cycle threshold values and identify SARS-CoV-2 viral loads in the nasopharynx as a major correlate of the systemic antibody response.
Keywords
- COVID-19
- coronavirus disease
- SARS-CoV-2
- severe acute respiratory syndrome coronavirus 2
- viruses
- respiratory infections
